Results 1 to 10 of about 1,809 (75)

Redundant mispair excision mechanisms in eukaryotic DNA mismatch repair [PDF]

Nucleus
DNA mismatch repair (MMR) corrects DNA replication errors, some forms of chemical damage to DNA bases, and acts in processes such as heteroduplex rejection, triplet repeat expansion, antibody maturation and cytotoxicity of alkylating agents.
Christopher D. Putnam, Richard D. Kolodner   +1 more
doaj   +2 more sources

Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα [PDF]

Nature Communications
TRDMT1 is an RNA methyltransferase that catalyzes 5-methylcytosine (m5C) formation in R-loops to promote transcription-coupled homologous recombination (TC-HR).
Arijit Ghosh, Xiaojuan Ran, Fengqi Zhang, Boya Gao, Yu Xu, Lai-Yee Phoon, Melissa Long, Mingchao Wang, Varsha Ananthapadmanabhan, Ajinkya Kawale, Yug Shah, Brenda Manzano-Winkler, Christopher J. Ott, Lee Zou, Li Lan   +14 more
doaj   +2 more sources

BRAF V600E and Mismatch Repair Proteins Expression in Sporadic Young-onset Colorectal Cancer in Kelantan, Malaysia

Oman Medical Journal, 2021
Objectives: We sought to determine the immunohistochemistry expression of mismatch repair (MMR) and BRAF V600E proteins in sporadic young-onset colorectal cancer (CRC) and their association with clinicopathological features in the Kelantan population ...
Zubaidah Saizul, Ab Hamid Siti-Azrin, Andee Dzulkarnaen Zakaria, Aniza Hassan, Wan Faiziah Wan Abdul Rahman, and Nur Asyilla Che Jalil   +5 more
doaj   +1 more source

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. [PDF]

PLoS Genetics, 2013
Lynch syndrome (hereditary nonpolypsis colorectal cancer or HNPCC) is a common cancer predisposition syndrome. Predisposition to cancer in this syndrome results from increased accumulation of mutations due to defective mismatch repair (MMR) caused by a ...
Catherine E Smith, Marc L Mendillo, Nikki Bowen, Hans Hombauer, Christopher S Campbell, Arshad Desai, Christopher D Putnam, Richard D Kolodner   +7 more
doaj   +1 more source

Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity. [PDF]

PLoS ONE, 2009
BACKGROUND:Human PMS2 (hPMS2) homologues act to nick 5' and 3' to misincorporated nucleotides during mismatch repair in organisms that lack MutH. Mn(++) was previously found to stimulate the endonuclease activity of these homologues. ATP was required for
Jerome Mauris, Thomas C Evans
doaj   +1 more source

MRE11A: a novel negative regulator of human DNA mismatch repair

Cellular & Molecular Biology Letters
Background DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR factors remain to be identified.
Demin Du, Yueyan Yang, Yuanyuan Zhang, Guanxiong Wang, Liying Chen, Xiaowei Guan, Lene Juel Rasmussen, Dekang Liu   +7 more
doaj   +1 more source

Mismatch Repair Endonuclease PMS2 [PDF]

, 2020
openaire   +1 more source

Prevalence of Mismatch Repair Deficiency and Its Association with Histopathological Parameters in Endometrial Cancer: A Prospective Cohort Study. [PDF]

Int J Mol Sci
Almperi EA, Margioula-Siarkou C, Almperis A, Zwimpfer TA, Daponte A, Daponte N, Vrekoussis T, Papamitsou T, Dinas K, Petousis S.   +9 more
europepmc   +1 more source

Pharmacologic Inhibition of PMS2 Induces MMR Deficiency and Response to Immune Checkpoint Blockade. [PDF]

Cancer Discov
Blagg J, Riou P, Hervieu A, Piumatti E, Rodriguez-Plata MT, Battuello P, Peall A, Amodio V, Vitiello PP, Nightingale DJH, Bago R, Tongue P, Slater T, Parmar K, Patel P, Rodríguez González J, Clark DE, Langley GW, Nichols C, Guarné A, Winship PCM, Baker M, Drysdale M, Germano G, Bardelli A.   +24 more
europepmc   +1 more source

Human PMS1-dependent non-canonical mismatch repair engages with MBD4 to repair methylated CpG deamination. [PDF]

Nucleic Acids Res
Le Ven A, Vanhuele S, Ganier O, Houy A, Kahn A, Rodrigues M, Stern MH, Guerois R, Silveira AB.   +8 more
europepmc   +1 more source