Results 41 to 50 of about 732,644 (123)

UEG Week 2023 Poster Presentations

, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 535-1498, October 2023.
wiley   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 222-242, June 2025.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers

International Journal of Cancer, Volume 156, Issue 7, Page 1393-1403, 1 April 2025.
What's new? A double primary colorectal cancer case in a familial setting signals a high risk of colorectal cancer. Here, the authors performed whole‐exome sequencing in nine patients with a double primary cancer and a family history of colorectal cancer to identify novel predisposition genes.
Asta Försti, Filip Ambrozkiewicz, Magdalena Marciniak, Jan Lubinski, Kari Hemminki   +4 more
wiley   +1 more source

Targeting the DNA damage response in cancer

MedComm, Volume 5, Issue 11, November 2024.
DNA damage response pathway can be effectively targeted with different small molecules inhibitors. They can be used in tumors with specific genetic defects (synthetic lethal approach), in combination with chemotherapy and radiotherapy, in combination with immune checkpoints and in the resistant setting. Abstract DNA damage response (DDR) pathway is the
Federica Guffanti, Michela Chiappa, Giovanna Damia   +2 more
wiley   +1 more source

Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma

Molecular Oncology, Volume 18, Issue 5, Page 1143-1173, May 2024.
Parvimonas micra can translocate from the oral cavity to the intestinal lumen, through the circulatory or gastrointestinal system, where the anaerobic bacteria undergoes some genome and transcriptomic changes needed for the adaptation to its new niche. P. micra can be considered as an excellent CRC biomarker detected in non‐invasive samples.
Kelly Conde‐Pérez, Elena Buetas, Pablo Aja‐Macaya, Elsa Martin‐De Arribas, Iago Iglesias‐Corrás, Noelia Trigo‐Tasende, Mohammed Nasser‐Ali, Lara S. Estévez, Soraya Rumbo‐Feal, Begoña Otero‐Alén, Jose F. Noguera, Ángel Concha, Simón Pardiñas‐López, Miguel Carda‐Diéguez, Igor Gómez‐Randulfe, Nieves Martínez‐Lago, Susana Ladra, Luis A. Aparicio, Germán Bou, Alex Mira, Juan A. Vallejo, Margarita Poza   +21 more
wiley   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +2 more sources

Genome Engineering as a Therapeutic Approach in Cancer Therapy: A Comprehensive Review

Advanced Genetics, Volume 5, Issue 1, March 2024.
Genome editing will change the future of cancer treatment, from generalized cancer treatment strategies toward a more personalized approach in cancer treatment, based on patient's genome, immune status, and the genetic profile of the tumor. Abstract Cancer is one of the foremost causes of mortality. The human genome remains stable over time.
Jack Gemayel, Alain Chebly, Hampig Kourie, Colette Hanna, Kayane Mheidly, Melissa Mhanna, Farah Karam, Daniel Ghoussaini, Paula El Najjar, Charbel Khalil   +9 more
wiley   +1 more source

Prime editing: Mechanism insight and recent applications in plants

Plant Biotechnology Journal, Volume 22, Issue 1, Page 19-36, January 2024.
Summary Prime editing (PE) technology utilizes an extended prime editing guide RNA (pegRNA) to direct a fusion peptide consisting of nCas9 (H840) and reverse transcriptase (RT) to a specific location in the genome. This enables the installation of base changes at the targeted site using the extended portion of the pegRNA through RT activity.
Tien V. Vu, Ngan Thi Nguyen, Jihae Kim, Jong Chan Hong, Jae‐Yean Kim   +4 more
wiley   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255), Copsey A., Prakash Arumugam, Sonya Newcombe (502072), Jordan, Philip W., Gray S., Alice Copsey (4460686), Alex D Herbert, Eva Hoffmann (159398), Li, Zhaobo, Shangming Tang, Zhaobo Li, Stephen Gray, Newnham, Louise, Herbert A.D., Chan, Andrew Chi-ho, Hannah G. Blitzblau (159462), Blitzblau, Hannah G., Gray, Stephen, Alex Herbert (725932), Hannah G Blitzblau, Hannah Blitzblau (5185454), Newcombe S., Tang, Shangming, Stephen Gray (3278418), Newnham L., Li Z., Hunter, Neil, Andrew Chi-ho Chan (3278421), Hochwagen, Andreas, Arumugam, Prakash, Shangming Tang (502071), Hochwagen A., Alice Copsey, Alice Copsey (502070), Copsey, Alice, Herbert, Alex D., Hoffmann E., Blitzblau H.G., Andreas Hochwagen (159466), Arumugam P., Louise Newnham, Neil Hunter, Philip W Jordan (16188074), Jordan P.W., Alex D. Herbert (502074), Philip W Jordan, Andrew Chi-Ho Chan, Louise Newnham (430862), Sonya Newcombe, Chan, Andrew Chi ho, Tang S., Prakash Arumugam (303310), Eva Hoffmann, Newcombe, Sonya, Andreas Hochwagen, Hunter N., Chan A.C.-h., Neil Hunter (155061), Steve Gray (5950955), Zhaobo Li (502073), Hoffmann, Eva   +61 more
core   +1 more source

Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]

, 2005
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I, Whitby, MC, Bjoras, M, Korvald, H, Tsaneva, I, Bjørås, M, Whitby, Matthew, Seeberg, E, Osman, F   +8 more
core   +1 more source