Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein [PDF]
, 2014 MUS81-EME1 is a conserved structure-selective endonuclease with a preference for branched DNA substrates in vitro that correspond to intermediates of DNA repair.
Rouse, John +3 more
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Hereditary colorectal cancer : assessment of genotype-phenotype correlations and analysis of rare susceptibility genes in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]
, 2008 Each year 3500 people in Switzerland are diagnosed with colorectal cancer. Approximately 20 percent of all affected patients have two or more first or second-degree relatives with colorectal cancer (at-risk family members). About five percent of these
Necker, Judith
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Endonuclease-independent DNA Mismatch Repair Processes on the Lagging Strand [PDF]
, 2018 DNA mismatch repair (MMR) pathways coordinate the excision and re-synthesis of newly-replicated DNA if a mismatched base-pair has been identified by protein MutS or MutS homologues (MSHs) after replication.
Josephs, Eric +1 more
core
Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition [PDF]
, 2012 The structure-specific endonuclease activity of the human XPF–ERCC1 complex is essential for a number of DNA processing mechanisms that help to maintain genomic integrity.
Lally, J. +5 more
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Investigating DNA remodeling in DNA mismatch repair
Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites,
Collingwood, Bryce William
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PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
, 2010 MutLα (MLH1–PMS2) is a latent endonuclease that is activated in a mismatch-, MutSα-, proliferating cell nuclear antigen (PCNA)-, replication factor C (RFC)-, and ATP-dependent manner, with nuclease action directed to the heteroduplex strand that contains
Ravi R. Iyer +5 more
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Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53 [PDF]
, 2013 YesThe antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C.
Phillips, Roger M. +9 more
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The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus [PDF]
, 2011 The human Suv3 helicase has been shown to be a major player in mitochondrial RNA surveillance and decay. In the present study we identify two new interaction partners of hSUV3: the RPA (replication protein A0 and FEN1 (flap endonuclease).
Stępień, Piotr P. +2 more
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Investigating strand specific iterative nicking in mismatch repair
In eukaryotic post-replicative DNA mismatch repair, MutS homolog complexes detect mismatches and in the major eukaryotic pathway, recruit multiple copies of the Mlh1-Pms1/MLH1-PMS2 (yeast/human) complex, which nick the newly replicated DNA strand upon ...
0000-0001-5725-0463 +1 more
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