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Pharmacokinetic Considerations of Misonidazole in Therapeutics
Human Toxicology, 1984The pharmacokinetics of misonidazole have been studied in 6 patients with special emphasis on determination of the peak concentration in plasma and saliva. Frequent sampling was performed over 4 h and a marked variation in absorption half-life (range 4 - 125 min) and time to peak range (0.5 - 6.5 h) was found.
I, Matheson, P N, Plowman, A, Johnston
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The effect of misonidazole on lymphocytes
The British Journal of Radiology, 1978Misonidazole (Ro 07–0582) is a radiosensitizer of hypoxic cells (Denekamp and Harris, 1975). Early studies with radiotherapy patients have been encouraging (Thomlinson et al., 1976). However, peak plasma levels of 100 μg/ml in patients have been associated with neurotoxicity (Dische et al., 1977).
M G, Clare, C A, Joslin
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Misonidazole-glutathione conjugates in CHO cells
International Journal of Radiation Oncology*Biology*Physics, 1984Misonidazole, after reduction to the hydroxylamine derivative, reacts with glutathione (GSH) under physiological conditions. The reaction product has been identified as a mixture of two isomeric conjugates. When water soluble extracts of CHO cells exposed to misonidazole under hypoxic conditions are subjected to HPLC analysis, misonidazole derivatives,
A J, Varghese, G F, Whitmore
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Misonidazole also radiosensitizes some normal tissue
The British Journal of Radiology, 1980Misonidazole is a radiosensitizer specific for hypoxic cells supposedly present only in tumours. We have been working with misonidazole in association with radiation, taking particular care to look for both local and general toxicity due to the drug per se and undesirable radiosensitization effects by the combined modality.
G, Arcangeli, C, Nervi, F, Mauro
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Loss of hearing after misonidazole
The British Journal of Radiology, 1980Neurotoxicity is regarded as the most significant side effect of the radiosensitizer misonidazole. Convulsions have been reported when the drug is used in high doses and sensory peripheral neuropathy with lower doses (Dische et al., 1977). Decreased hearing of short term duration has been reported by Wasserman et al.
R. P. Abratt, J. D. Blackburn
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Nature and Incidence of Misonidazole-Produced Ototoxicity
Archives of Otolaryngology - Head and Neck Surgery, 1981Misonidazole, a potent new antitumor agent that selectively increases the effect of ionizing radiations on poorly oxygenated tumor tumor cells, was given to 21 patients at New York University-Bellevue Medical Center. In 11 of the 21 patients, hearing loss developed secondary to drug ingestion.
S B, Waltzman, J S, Cooper
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The British Journal of Radiology, 1987
The misonidazole (MISO) “pre-incubation” effect, whereby the sensitiser-enhancement ratio (SER) is increased following prolonged exposure of cells in hypoxia to MISO, was first demonstrated by Hall and Biaglow (1977). Subsequently, Wong et al (1978) showed that hypoxic cells incubated with 0.5 mM MISO for several hours at 37°C had an increased ...
N J, McNally +3 more
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The misonidazole (MISO) “pre-incubation” effect, whereby the sensitiser-enhancement ratio (SER) is increased following prolonged exposure of cells in hypoxia to MISO, was first demonstrated by Hall and Biaglow (1977). Subsequently, Wong et al (1978) showed that hypoxic cells incubated with 0.5 mM MISO for several hours at 37°C had an increased ...
N J, McNally +3 more
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Flash Photolysis of Misonidazole and Metronidazole
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1987Laser flash photolysis at 355 nm of misonidazole or metronidazole in aqueous solutions produced the relatively long-lived nitro radical anion as the only observable transient species. When 266 nm excitation was used, a small yield of solvated electron was observed.
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Enhancement of artificial lung metastases by misonidazole
International Journal of Radiation Oncology*Biology*Physics, 1984The effect of treatment with the hypoxic cell radiosensitizer misonidazole on the formation of artificial lung metastases was examined. Both single treatments with large doses of misonidazole and fractionated treatments with smaller doses of misonidazole were found to increase the number of lung tumors developing after intravenous injection of EMT6 ...
S, Rockwell, M, Nierenburg, C G, Irvin
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Somatosensory deficits in monkeys treated with misonidazole
Toxicology and Applied Pharmacology, 1981Misonidazole, a hypoxic cell radiosensitizer, can produce peripheral sensory disorders in humans. It has been studied in monkeys with a computer-controlled system for evaluating vibration sensitivity. Monkeys were trained to report when vibration was stimulating the finger tip. Sinusoidal vibrations of several frequencies were presented.
J P, Maurissen +5 more
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