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Drugs of the Future, 1977 Some of the next articles are maybe not open access.
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The effect of misonidazole on lymphocytes
The British Journal of Radiology, 1978Misonidazole (Ro 07–0582) is a radiosensitizer of hypoxic cells (Denekamp and Harris, 1975). Early studies with radiotherapy patients have been encouraging (Thomlinson et al., 1976). However, peak plasma levels of 100 μg/ml in patients have been associated with neurotoxicity (Dische et al., 1977).
M G, Clare, C A, Joslin
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The pharmacokinetics of misonidazole in the dog
European Journal of Cancer (1965), 1979Abstract The hypoxic cell radiosensitising drug misonidazole, [ 1 -( 2 -nitroimidazol- 1 -yl)- 3 -methoxypropan- 2 -ol, Ro 07-0582 ] was administered to dogs at dose levels of 50–200 mg/kg on four consecutive weekly occasions by oral and intravenous routes.
R A, White +4 more
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Comparison of Binding of [ 3 H]Misonidazole and [ 14 C]Misonidazole in Multicell Spheroids
Radiation Research, 1985Uptake of [2-ring-14C]misonidazole and [3H]misonidazole with tritium in the side chain has been compared in 1-mm EMT-6/UW spheroids using liquid scintillation counting and autoradiography. The uptake of both labeled sensitizers as a function of incubation time was virtually identical.
J S, Rasey +4 more
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Pharmacokinetic Considerations of Misonidazole in Therapeutics
Human Toxicology, 1984The pharmacokinetics of misonidazole have been studied in 6 patients with special emphasis on determination of the peak concentration in plasma and saliva. Frequent sampling was performed over 4 h and a marked variation in absorption half-life (range 4 - 125 min) and time to peak range (0.5 - 6.5 h) was found.
I, Matheson, P N, Plowman, A, Johnston
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Neurotoxicity of adriamycin and misonidazole in the mouse
Experimental Neurology, 1985The neurotoxicity of the anticancer drug adriamycin was investigated in the peripheral nerve of the mouse. Injection of adriamycin into the sciatic nerve resulted in biochemical and morphologic signs of severe axonal degeneration. The biochemical evidence was based on marked increases in lysosomal enzyme activity.
R J, Boegman +3 more
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Glutathione conjugates of misonidazole
Biochemical and Biophysical Research Communications, 1983The hydroxylamine derivative of misonidazole reacts with glutathione under physiological conditions to form two isomeric conjugates. Based on physical and chemical properties, the two conjugates have been identified as 1-[2-amino-(4-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol and 1-[2-amino-(5-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol.
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Enhancement of Misonidazole Cytotoxicity by Iron
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1985The toxicity of misonidazole (MISO) to hypoxic Chinese hamster ovary (CHO) cells in serum-free medium is enhanced by Fe(III)-EDTA. Enhancement of MISO cytotoxicity by a factor of 1.6 was seen with 2 microM Fe(III)-EDTA, while 200 microM Fe(III)-EDTA results in sensitization by a factor of 2.0.
A, Samuni +3 more
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Stable reduction product of misonidazole
International Journal of Radiation Oncology*Biology*Physics, 1986The predominant stable product (greater than 80%) of the anaerobic radiation chemical reduction (pH 7, formate, N2O) of misonidazole (MISO) has been identified as the cyclic guanidinium ion MISO-DDI, a 4,5-dihydro-4,5-dihydroxyimidazolium ion. This cation was prepared as its sulfate salt by the reaction of glyoxal and the appropriate N-substituted ...
R, Panicucci +2 more
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