C3H マウス シゼン ハッセイ ニュウガン ニ タイスル ホウシャセン Misonidazole オヨビ 5-Fluorouracil ノ ヘイヨウ コウカ [PDF]
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Misonidazole neuropathy A prospective study
Journal of Neuro-Oncology, 1988The frequency with which polyneuropathy developed was investigated in patients with cancer of the larynx and pharynx who participated in a double-blind trial of the radiosensitizing drug misonidazole. Fourteen of 36 patients receiving misonidazole (total dose of about 11 g/m2) developed neuropathy, while this occurred in only 2 of 34 patients in the ...
Jens Overgaard, O B Paulson
exaly +5 more sources
Enhancement of artificial lung metastases by misonidazole
International Journal of Radiation Oncology Biology Physics, 1984The effect of treatment with the hypoxic cell radiosensitizer misonidazole on the formation of artificial lung metastases was examined. Both single treatments with large doses of misonidazole and fractionated treatments with smaller doses of misonidazole were found to increase the number of lung tumors developing after intravenous injection of EMT6 ...
S, Rockwell, M, Nierenburg, C G, Irvin
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The effect of misonidazole on lymphocytes
The British Journal of Radiology, 1978Misonidazole (Ro 07–0582) is a radiosensitizer of hypoxic cells (Denekamp and Harris, 1975). Early studies with radiotherapy patients have been encouraging (Thomlinson et al., 1976). However, peak plasma levels of 100 μg/ml in patients have been associated with neurotoxicity (Dische et al., 1977).
M G, Clare, C A, Joslin
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The pharmacokinetics of misonidazole in the dog
European Journal of Cancer (1965), 1979Abstract The hypoxic cell radiosensitising drug misonidazole, [ 1 -( 2 -nitroimidazol- 1 -yl)- 3 -methoxypropan- 2 -ol, Ro 07-0582 ] was administered to dogs at dose levels of 50–200 mg/kg on four consecutive weekly occasions by oral and intravenous routes.
R A, White +4 more
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Comparison of Binding of [ 3 H]Misonidazole and [ 14 C]Misonidazole in Multicell Spheroids
Radiation Research, 1985Uptake of [2-ring-14C]misonidazole and [3H]misonidazole with tritium in the side chain has been compared in 1-mm EMT-6/UW spheroids using liquid scintillation counting and autoradiography. The uptake of both labeled sensitizers as a function of incubation time was virtually identical.
J S, Rasey +4 more
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