Results 141 to 150 of about 2,799 (186)
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Glutathione Depletion and Misonidazole Efficiency
The British Journal of Radiology, 1985Shrieve and Denekamp (1985) conclude that misonidazole (MISO) is not more efficient in GSH-depleted cells than in untreated cells. They point out that although their experimental studies on the radiosensitisation of GSH-depleted hypoxic cells by oxygen or MISO (Shrieve et al, 1984) are similar to those of others in the literature, their conclusion is ...
J M, Brown, E A, Bump
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2000
Abstract Misonidazole, a 2-nitroimidazole compound, is a hypoxic cell radiosensitizer used to sensitize radioresistant tumor cells. Neurotoxicity consists of a dose-limiting, predominantly sensory peripheral neuropathy and, at high doses, encephalopathy.
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Abstract Misonidazole, a 2-nitroimidazole compound, is a hypoxic cell radiosensitizer used to sensitize radioresistant tumor cells. Neurotoxicity consists of a dose-limiting, predominantly sensory peripheral neuropathy and, at high doses, encephalopathy.
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Misonidazole and potentially lethal damage
International Journal of Radiation Oncology*Biology*Physics, 1982The existence of potentially lethal damage (PLD) is demonstrated in exponentially growing CHO cells exposed to misonidazole in hypoxia. The method of hypertonic post-treatment of cells was used in these studies. Misonidazole-induced PLD differs in many characteristics from radiation-induced PLD.
M, Korbelik +3 more
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Flash Photolysis of Misonidazole and Metronidazole
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1987Laser flash photolysis at 355 nm of misonidazole or metronidazole in aqueous solutions produced the relatively long-lived nitro radical anion as the only observable transient species. When 266 nm excitation was used, a small yield of solvated electron was observed.
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The Radiation Reduction of Misonidazole
Radiation Research, 1981[14C]Misonidazole, a 2-nitroimidazole radiation sensitizer, was reduced in dilute aqueous solution by irradiation in the absence of oxygen and in the presence of excess formate ions. In solutions buffered at pH 7.0 the misonidazole absorption spectrum is lost with increasing radiation exposure, consuming 4.0 + 0.2 reducing equivalents per molecule ...
D. W. Whillans, G. F. Whitmore
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Acta neurologica Scandinavica. Supplementum, 1984
Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
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Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
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The British Journal of Radiology, 1987
The misonidazole (MISO) “pre-incubation” effect, whereby the sensitiser-enhancement ratio (SER) is increased following prolonged exposure of cells in hypoxia to MISO, was first demonstrated by Hall and Biaglow (1977). Subsequently, Wong et al (1978) showed that hypoxic cells incubated with 0.5 mM MISO for several hours at 37°C had an increased ...
N J, McNally +3 more
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The misonidazole (MISO) “pre-incubation” effect, whereby the sensitiser-enhancement ratio (SER) is increased following prolonged exposure of cells in hypoxia to MISO, was first demonstrated by Hall and Biaglow (1977). Subsequently, Wong et al (1978) showed that hypoxic cells incubated with 0.5 mM MISO for several hours at 37°C had an increased ...
N J, McNally +3 more
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Modification of the Action of Misonidazole Effect of TAN on Radiosensitization
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1980Radiosensitization by misonidazole of hypoxic mammalian cells in dilute suspension is modified by the presence of the stable free radical, TAN. The dose modifying factor (DMF) of 15mM misonidazole is 2x4 for cell inactivation, and 3x5 for the production of single-strand breaks in DNA.
K A, Skov +3 more
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Cellular and chemical reduction products of misonidazole
Chemico-Biological Interactions, 1981Misonidazole is readily reduced by zinc dust in aqueous solution in the presence of ammonium chloride. High pressure liquid chromatographic (HPLC) separation of the reduction mixture revealed the presence of three products. These were identified as the hydroxylamine, amine and the hydrazo derivative of misonidazole.
A J, Varghese, G F, Whitmore
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Somatosensory deficits in monkeys treated with misonidazole
Toxicology and Applied Pharmacology, 1981Misonidazole, a hypoxic cell radiosensitizer, can produce peripheral sensory disorders in humans. It has been studied in monkeys with a computer-controlled system for evaluating vibration sensitivity. Monkeys were trained to report when vibration was stimulating the finger tip. Sinusoidal vibrations of several frequencies were presented.
J P, Maurissen +5 more
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