Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Knight, J.R.P. +5 more
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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Nature Communications, 2016 Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde +1 more
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Cell Reports, 2015 Intestinal epithelial homeostasis requires continuous renewal supported by stem cells located in the base of the crypt. Disruption of this balance results in failure to regenerate and initiates tumorigenesis.
Victoria Llado +11 more
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Rapid Delivery of Gold Nanoparticles into Colon Cancer HT-29 Cells by Electroporation: In-vitro Study [PDF]
Journal of Biomedical Physics and Engineering, 2020 Background: Electroporation has become a routine technique for rapid drug delivery for the treatment of cancer. Because of its simplicity and wide range of application, it has been applied for the transfer of gold-nanoparticles and can facilitate entry ...
Z Arab-Bafrani +2 more
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Cell Death and Disease, 2022 Cancer genomics and cancer mutation databases have made an available wealth of information about missense mutations found in cancer patient samples. Contextualizing by means of annotation and predicting the effect of amino acid change help identify which
Matteo Tiberti +6 more
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Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
Cell Reports, 2015 The mTORC1 complex is central to the cellular response to changes in nutrient availability. The signaling adaptor p62 contributes to mTORC1 activation in response to amino acids and interacts with TRAF6, which is required for the translocation of mTORC1 ...
Juan F. Linares +6 more
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Socio-economic inequalities in testicular cancer survival within two clinical studies. [PDF]
, 2012 BACKGROUND: Testicular cancer is the most common cancer in men under 35 years of age, and has the highest survival for adult male malignancies. Despite the fact that survival is very high, there is evidence that survival differs between socio-economic ...
Read, Graham +23 more
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CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells
Frontiers in Molecular Neuroscience, 2017 Neuroblastoma is the most common solid extra cranial tumor in infants. Improving the clinical outcome of children with aggressive tumors undergoing one of the multiple treatment options has been a major concern.
Namrata Chaudhari +3 more
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The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]
, 2010 <b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Meek, C.L. +3 more
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NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling [PDF]
, 2011 Moderate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS
Rosc-Schlüter, Berit Ines
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