Results 1 to 10 of about 3,358,181 (305)

Immune Microenvironment in Hematologic Malignancies [PDF]

Iranian Journal of Medical Sciences, 2023
The role of the tumor microenvironment (TME), especially immune cell compartments, in tumor progression is inevitable and the heterogeneity and complexity of the TME-associated immune cells make it challenging to provide appropriate treatments for ...
Nargess Arandi, Mehdi Dehghani
doaj   +1 more source

PTEN-lipid Binding Assay

Bio-Protocol, 2013
The lipid and protein interactions are an integral and important part of many cellular signaling pathways. The understanding of the selective and specific interaction of the given lipid molecule with the target protein is required for studying cellular ...
Sridhar Kavela, Swapnil Shinde, Subbareddy Maddika   +2 more
doaj   +1 more source

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]

, 2015
B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E, Ley, SC, Schweighoffer, E, Tybulewicz, VL   +3 more
core   +1 more source

BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]

, 2017
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim, Barrett, Christine M. Eischen, Clare M. Adams, Gibson, Haldar, Jerald Z. Gong, John K. Choi, Lee, Placzek, Ramkrishna Mitra, Schmitz, Visco, Wang, Yang   +14 more
core   +2 more sources

Evaluación de formas cortas de extrasístoles auriculares recurrentes mediante ecocardiografía con deformación auricular izquierda en pacientes ambulatorios sin cardiopatía orgánica

Archivos de Cardiología de México, 2023
Objetivo: Analizar la utilidad y relevancia clínica de la evaluación mediante ecocardiografía basada en las curvas de deformación auricular miocárdica con imágenes vectoriales de velocidad (VVI) de speckle-tracking, en el análisis de las extrasístoles ...
José M. Soler, Gemma García-Parés, Oliver Valero, Antonio Berruezo, Victor J. Yuste, María Antonia Baltrons   +5 more
doaj   +1 more source

Constitutive IP₃ signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP₃ receptor disruptor BIRD-2 [PDF]

, 2018
Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5 ...
Akl, Haidar, Baes, Myriam, Bittremieux, Mart, Bootman, Martin D., Bultynck, Geert, De Smedt, Humbert, Dubron, Kathia, Efremov, Dimitar G., Janssens, Ann, La Rovere, Rita M., Laurenti, Luca, Martines, Claudio, Mikoshiba, Katsuhiko, Morciano, Giampaolo, Parys, Jan B., Pinton, Paolo, Rietdorf, Katja, Vandenberghe, Peter, Welkenhuyzen, Kirsten   +18 more
core   +3 more sources

Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes

Particle and Fibre Toxicology, 2021
Background Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability. Results In this study, nano-sized (30–300 nm) plastic particles were isolated from the commercial face ...
Ponnusamy Manogaran Gopinath, Krishna Sundar Twayana, Palaniyandi Ravanan, John Thomas, Amitava Mukherjee, David F. Jenkins, Natarajan Chandrasekaran   +6 more
doaj   +1 more source

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]

, 2012
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
A Barbarulo, A Chaidos, A Karadimitris, A Rahemtulla, AJ Bardwell, C Bubici, C-H Yoon, CG Pham, CR Geest, D Chauhan, D O Haskard, E Spanoudakis, EF Wagner, F Bost, F Zazzeroni, F Zhan, F Zhan, G Franzoso, H Ke, H Ke, J Cui, J Cui, J Ford, J Liu, K Kim, K Naresh, K Pruitt, K Sabapathy, KC Anderson, KN Naresh, L Aravind, L Hui, LC Platanias, M Anbalagan, M Blonska, M Gururajan, M Hallek, M Raman, M Wiznerowicz, MA Bogoyevitch, MA Bogoyevitch, MS Raab, N Chen, NJ Kennedy, NN Gangopadhyay, RT Nitta, S Goenka, S Goenka, S Papa, S Papa, SH Cho, SH Cho, SU Ahmed, SV Rajkumar, T Hideshima, T Hideshima, T Hideshima, T Kajiguchi, T Yanagawa, TE Witzig, V Brune, V Iansante, V Schreiber, YM Yang   +63 more
core   +2 more sources

Gene trapping identifies transiently induced survival genes during programmed cell death [PDF]

, 2001
Background: The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and, if such factors are unavailable, cells die by default.
Wempe, Frank, Yang, Ji-Yeon, Hammann, Joanna, Melchner, Harald von (Prof. Dr.)   +3 more
core   +1 more source

PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly

Cell Reports, 2017
Summary: The tumor suppressor PTEN executes cellular functions predominantly through its phosphatase activity. Here we identified a phosphatase-independent role for PTEN during vesicular trafficking of the glucose transporter GLUT1.
Swapnil Rohidas Shinde, Subbareddy Maddika   +1 more
doaj   +1 more source