Results 11 to 20 of about 8,088,933 (310)

MAP4K4 inhibition promotes survival of human stem cell derived cardiomyocyte and reduces infarct size in vivo [PDF]

, 2019
Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has
Paiva, MA, Michael, LH, Song, W, Kanayaganam, S, Xie, M, Taffet, GE, Harding, SE, Pavanello, L, Aqil, R, Bellahcene, M, Maifosie, E, Jarvis, A, Wang, SC, Tralau-Stewart, C, Habib, J, Perrior, T, Narasimham, P, Fiedler, Lorna, Newton, G, Golforoush, PA, Noseda, M, Sampson, RD, Bellahcene, Mohamed, Tan, T, Fiedler, LR, Golforoush, Pelin, Jenkins, M, Sano, M, Schneider, MD, Entman, ML, Chapman, K, Faust, D, Tan, T-H, Harding, Sian, Noseda, Michela, Sanmugalingam, D, Schneider, Michael, Stuckey, DJ, Yan, R, Maifoshie, E, Narasimhan, P, Low, CMR, Harada, M   +42 more
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PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells [PDF]

, 2020
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Kuster, B., Chennupati, V, Tiganis, T, Cullen, J.G., Flosbach, M, von Hoesslin, M., Oberle, SG, von Hoesslin, M, List, M, List, M., Zecha, J, Pauling, JK, Zecha, J., Tiganis, T., Chennupati, V., Wiede, F, Baumbach, J., Baumbach, J, Pauling, J.K., Zehn, D, Scherer, S., Wiede, F., Oberle, S.G., Kuster, B, Scherer, S, Flosbach, M., Zehn, D., Cullen, JG   +27 more
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Gene trapping identifies transiently induced survival genes during programmed cell death [PDF]

, 2001
Background: The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and, if such factors are unavailable, cells die by default.
Yang, Ji-Yeon, Hammann, Joanna, Wempe, Frank, Melchner, Harald von (Prof. Dr.)   +3 more
core   +1 more source

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source

The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004. [PDF]

, 2009
BACKGROUND: Extrapulmonary small cell carcinoma (EPSCC) is a rare cancer and few studies describe its epidemiology. Our objectives were to compare the incidence and survival of EPSCC in South East England with small cell carcinoma of the lung (SCLC), to ...
Jack, Ruth H, Jack Ruth H, Elizabeth A Davies, Jack, Ruth H., Wong Yien, Davies, Elizabeth A.; id_orcid, Henrik Møller, Mak, Vivian, Møller Henrik, Vivian Mak, Wong, Yien Ning S., Mak Vivian, Henrik, Moller; id_orcid, Yien Ning S Wong, Ruth H Jack, Davies Elizabeth A, Henrik, Møller, Davies, Elizabeth A, Wong, Yien Ning S   +18 more
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Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery [PDF]

, 2014
Background:Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique.
Fleming, S., P Rauchhaus, J Fitzpatrick, Fitzpatrick, J., N Pratt, S Fleming, J Bondad, J Cunningham, El-Mokadem, I., Cunningham, J., Bondad, J., Nabi, G., Rauchhaus, P., G Nabi, Pratt, N., I El-Mokadem   +15 more
core   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Knight, J.R.P., Knight, J. R. P., Knight, John R.P.; id_orcid, Milner, J., Allison, Simon J., Milner, Jo   +5 more
core   +1 more source

Isolation and Characterization of Crab Haemolymph Exosomes and Its Effects on Breast Cancer Cells (4T1) [PDF]

Cell Journal, 2021
Objective: The use of animal or plant exosomes in cancer treatment is promising because of their easy access and low cost. Freshwater crabs are used in traditional Iranian medicine to treat cancer.
Leila Rezakhani, Morteza Alizadeh, Esmaeel Sharifi, Mostafa Soleimannejad, Akram Alizadeh   +4 more
doaj   +1 more source

p63, Cell Adhesion and Survival [PDF]

Cell Cycle, 2007
The development of stratified epithelia and their derivatives is a complex process requiring a multifaceted transcriptional program. p63, the p53-related transcription factor, is fundamental to this process. However, the underlying mechanisms by which p63 exerts its influence on stratified epithelial development and integrity remain elusive.
Danielle K, Carroll, Joan S, Brugge, Laura D, Attardi   +2 more
openaire   +2 more sources

The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma

Cell Death and Disease, 2022
Cancer genomics and cancer mutation databases have made an available wealth of information about missense mutations found in cancer patient samples. Contextualizing by means of annotation and predicting the effect of amino acid change help identify which
Matteo Tiberti, Luca Di Leo, Mette Vixø Vistesen, Rikke Sofie Kuhre, Francesco Cecconi, Daniela De Zio, Elena Papaleo   +6 more
doaj   +1 more source