Results 11 to 20 of about 2,251,671 (317)

MAP4K4 inhibition promotes survival of human stem cell derived cardiomyocyte and reduces infarct size in vivo [PDF]

, 2019
Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has
Paiva, MA, Michael, LH, Song, W, Kanayaganam, S, Xie, M, Taffet, GE, Harding, SE, Pavanello, L, Aqil, R, Bellahcene, M, Maifosie, E, Jarvis, A, Wang, SC, Tralau-Stewart, C, Habib, J, Perrior, T, Narasimham, P, Fiedler, Lorna, Newton, G, Golforoush, PA, Noseda, M, Sampson, RD, Bellahcene, Mohamed, Tan, T, Fiedler, LR, Golforoush, Pelin, Jenkins, M, Sano, M, Schneider, MD, Entman, ML, Chapman, K, Faust, D, Tan, T-H, Harding, Sian, Noseda, Michela, Sanmugalingam, D, Schneider, Michael, Stuckey, DJ, Yan, R, Maifoshie, E, Narasimhan, P, Low, CMR, Harada, M   +42 more
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Immune Microenvironment in Hematologic Malignancies [PDF]

Iranian Journal of Medical Sciences, 2023
The role of the tumor microenvironment (TME), especially immune cell compartments, in tumor progression is inevitable and the heterogeneity and complexity of the TME-associated immune cells make it challenging to provide appropriate treatments for ...
Nargess Arandi, Mehdi Dehghani
doaj   +1 more source

Oncogenes in Cell Survival and Cell Death [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
The transforming effects of proto-oncogenes such as MYC that mediate unrestrained cell proliferation are countered by "intrinsic tumor suppressor mechanisms" that most often trigger apoptosis. Therefore, cooperating genetic or epigenetic effects to suppress apoptosis (e.g., overexpression of BCL2) are required to enable the dual transforming processes ...
Jake, Shortt, Ricky W, Johnstone
openaire   +2 more sources

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells [PDF]

, 2020
Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Kuster, B., Chennupati, V, Tiganis, T, Cullen, J.G., Flosbach, M, von Hoesslin, M., Oberle, SG, von Hoesslin, M, List, M, List, M., Zecha, J, Pauling, JK, Zecha, J., Tiganis, T., Chennupati, V., Wiede, F, Baumbach, J., Baumbach, J, Pauling, J.K., Zehn, D, Scherer, S., Wiede, F., Oberle, S.G., Kuster, B, Scherer, S, Flosbach, M., Zehn, D., Cullen, JG   +27 more
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PTEN-lipid Binding Assay

Bio-Protocol, 2013
The lipid and protein interactions are an integral and important part of many cellular signaling pathways. The understanding of the selective and specific interaction of the given lipid molecule with the target protein is required for studying cellular ...
Sridhar Kavela, Swapnil Shinde, Subbareddy Maddika   +2 more
doaj   +1 more source

Evaluación de formas cortas de extrasístoles auriculares recurrentes mediante ecocardiografía con deformación auricular izquierda en pacientes ambulatorios sin cardiopatía orgánica

Archivos de Cardiología de México, 2023
Objetivo: Analizar la utilidad y relevancia clínica de la evaluación mediante ecocardiografía basada en las curvas de deformación auricular miocárdica con imágenes vectoriales de velocidad (VVI) de speckle-tracking, en el análisis de las extrasístoles ...
José M. Soler, Gemma García-Parés, Oliver Valero, Antonio Berruezo, Victor J. Yuste, María Antonia Baltrons   +5 more
doaj   +1 more source

Cellular stress responses: cell survival and cell death [PDF]

, 2010
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells.
Afshin Samali, Hori, Osamu, Gorman, Adrienne M., 26106, Fulda, Simone, 26105, Samali, Afshin, 26107, 60303947, 233, Simone Fulda, Osamu Hori, Adrienne M. Gorman   +12 more
core   +1 more source

Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes

Particle and Fibre Toxicology, 2021
Background Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability. Results In this study, nano-sized (30–300 nm) plastic particles were isolated from the commercial face ...
Ponnusamy Manogaran Gopinath, Krishna Sundar Twayana, Palaniyandi Ravanan, John Thomas, Amitava Mukherjee, David F. Jenkins, Natarajan Chandrasekaran   +6 more
doaj   +1 more source

The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970-2004. [PDF]

, 2009
BACKGROUND: Extrapulmonary small cell carcinoma (EPSCC) is a rare cancer and few studies describe its epidemiology. Our objectives were to compare the incidence and survival of EPSCC in South East England with small cell carcinoma of the lung (SCLC), to ...
Jack, Ruth H, Jack Ruth H, Elizabeth A Davies, Jack, Ruth H., Wong Yien, Davies, Elizabeth A.; id_orcid, Henrik Møller, Mak, Vivian, Møller Henrik, Vivian Mak, Wong, Yien Ning S., Mak Vivian, Henrik, Moller; id_orcid, Yien Ning S Wong, Ruth H Jack, Davies Elizabeth A, Henrik, Møller, Davies, Elizabeth A, Wong, Yien Ning S   +18 more
core   +1 more source

Cell Survival Signaling in Neuroblastoma [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2013
Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal cellular senescence or apoptosis.
Michael L, Megison, Lauren A, Gillory, Elizabeth A, Beierle   +2 more
openaire   +2 more sources