Results 31 to 40 of about 3,358,181 (305)
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]
, 2017 Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E +11 more
core +1 more source
Frontiers in Physiology, 2020 Dementia is one among the consequences of aging, and amnesia is often one of the most common symptoms. The lack of memory, as a consequence of both “healthy” aging or neurodegenerative conditions, such as in Alzheimer’s disease, has a dramatic impact on ...
Flavia Messina +4 more
doaj +1 more source
Autophagy in Viral Development and Progression of Cancer
Frontiers in Oncology, 2021 Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases.
Alejandra Suares +5 more
doaj +1 more source
Targeting tachykinin receptors in neuroblastoma [PDF]
, 2016 Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%.
Althoff, Kristina +14 more
core +3 more sources
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
Neurobiology of Disease, 2005 We investigated whether cell proliferation and neurogenesis are altered in R6/2 transgenic Huntington's disease mice. Using bromodeoxyuridine (BrdU), we found a progressive decrease in the number of proliferating cells in the dentate gyrus of R6/2 mice ...
Joana M.A.C. Gil +6 more
doaj +1 more source
BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis
Autophagy ReportsEpithelial and endothelial barriers are essential for tissue homeostasis, protecting the body from environmental insults while regulating selective transport. The integrity of these barriers relies on dynamic intercellular junctions whose composition and
Juliani Juliani +2 more
doaj +1 more source
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival [PDF]
, 2017 LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology.
Gilder, Andrew S. +4 more
core +3 more sources
Autophagy ReportsDisrupted intestinal homeostasis and barrier function contribute to the development of diseases such as inflammatory bowel disease. BECLIN-1, a core component of two class III phosphatidylinositol 3 kinase complexes, has a dual role in autophagy and ...
Juliani Juliani +10 more
doaj +1 more source
Renal papillary carcinoma developed in a kidney transplant recipient with late IgA-nephropathy [PDF]
, 2016 With improvements in immunosuppressive therapy, patient and graft survival in renal transplant recipients have been prolonged. Increasing donor age and patient survival rates have been related to an increase in the number of de novo tumors ...
BERLOCO, Pasquale Bartolomeo +7 more
core +1 more source
Mediators of Inflammation, 2015 Oxidative and nitrosative stresses have been reported as detrimental phenomena concurring to the onset of several neurodegenerative diseases. Here we reported that the ectopic modulation of the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR)
Salvatore Rizza +8 more
doaj +1 more source