Results 41 to 50 of about 8,088,933 (310)
Mediators of Inflammation, 2015 Oxidative and nitrosative stresses have been reported as detrimental phenomena concurring to the onset of several neurodegenerative diseases. Here we reported that the ectopic modulation of the denitrosylating enzyme S-nitrosoglutathione reductase (GSNOR)
Salvatore Rizza +8 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Signalling for B cell survival. [PDF]
, 2017 The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell antigen receptor (BCR) and BAFFR.
Tybulewicz, VL, Schweighoffer, E
core +1 more source
Survival mechanisms in B lymphoid malignancies and associated therapies [PDF]
, 2011 PhDThe apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and
Su, Bo
core +4 more sources
Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex
EMBO ReportsmTOR (mechanistic target of rapamycin) kinase is a pivotal regulator of cellular growth and metabolism, integrating signals from nutrients and growth factors. It functions through the assembly of two distinct complexes, mTORC1 and mTORC2, which differ in
Keshav Gupta +4 more
doaj +1 more source
A LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axis
iScienceSummary: LisH-domain-containing proteins are involved in diverse cellular processes and disease mechanisms, yet their functional interaction landscape remains poorly characterized.
Devanshi Gupta, Subbareddy Maddika
doaj +1 more source
Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells
Frontiers in Endocrinology, 2020 Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo +11 more
doaj +1 more source
Vesicular Zinc Modulates Cell Proliferation and Survival in the Developing Hippocampus
Cells, 2023 In the brain, vesicular zinc, which refers to a subset of zinc that is sequestered into synaptic vesicles by zinc transporter 3 (ZnT3), has extensive effects on neuronal signalling and modulation.
Selena Fu +3 more
doaj +1 more source
Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Dark-Induced Barley Leaf Senescence – A Crop System for Studying Senescence and Autophagy Mechanisms
Frontiers in Plant Science, 2021 This review synthesizes knowledge on dark-induced barley, attached, leaf senescence (DILS) as a model and discusses the possibility of using this crop system for studying senescence and autophagy mechanisms.
Ewelina Paluch-Lubawa +2 more
doaj +1 more source