Results 51 to 60 of about 3,358,181 (305)

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Nrf2 signaling and cell survival [PDF]

Toxicology and Applied Pharmacology, 2010
Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K, Niture, James W, Kaspar, Jun, Shen, Anil K, Jaiswal   +3 more
openaire   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Renalase: A Multi-Functional Signaling Molecule with Roles in Gastrointestinal Disease

Cells, 2021
The survival factor renalase (RNLS) is a recently discovered secretory protein with potent prosurvival and anti-inflammatory effects. Several evolutionarily conserved RNLS domains are critical to its function.
Thomas C. Pointer, Fred S. Gorelick, Gary V. Desir   +2 more
doaj   +1 more source

Preoperative CYFRA 21-1 and CEA as Prognostic Factors in Patients with Stage I Non-Small Cell Lung Cancer [PDF]

, 2008
Objective: To validate the prognostic value of preoperative levels of CYFRA 21-1, CEA and the corresponding tumor marker index (TMI) in patients with stage I non-small cell lung cancer (NSCLC). Methods: Two hundred forty stage I NSCLC patients (80 in pT1
Ankerst, Donna Pauler, Blankenburg, Florian, Gruber, Christine, Hatz, Rudolf, Nagel, Dorothea, Reinmiedl, Judith, Seidel, Dietrich, Stieber, Petra   +7 more
core   +1 more source

Giant cells: multiple cells unite to survive

Frontiers in Cellular and Infection Microbiology, 2023
Multinucleated Giant Cells (MGCs) are specialized cells that develop from the fusion of multiple cells, and their presence is commonly observed in human cells during various infections. However, MGC formation is not restricted to infections alone but can also occur through different mechanisms, such as endoreplication and abortive cell cycle.
Shreyasee Hazra, Suman Kalyan Dinda, Naba Kumar Mondal, Sk Rajjack Hossain, Pratyay Datta, Afsana Yasmin Mondal, Pushkar Malakar, Dipak Manna   +7 more
openaire   +3 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice

Neurobiology of Disease, 2011
Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic ...
Jorien M.M. van der Burg, Annika Winqvist, N. Ahmad Aziz, Marion L.C. Maat-Schieman, Raymund A.C. Roos, Gillian P. Bates, Patrik Brundin, Maria Björkqvist, Nils Wierup   +8 more
doaj   +1 more source

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer [PDF]

, 2016
The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an ...
Edwards, J., Horgan, P. G., McMillan, D. C., Park, J. H., Roxburgh, Campbell S.D.   +4 more
core   +1 more source

Cancer cells survive with survivin

Cancer Science, 2008
Survivin has multiple functions including cytoprotection, inhibition of cell death, and cell‐cycle regulation, especially at the mitotic process stage, all of which favor cancer survival. Many studies on clinical specimens have shown that survivin expression is invariably up‐regulated in human cancers and is associated with resistance to chemotherapy ...
Hirofumi, Yamamoto, Chew Yee, Ngan, Morito, Monden   +2 more
openaire   +2 more sources