Results 61 to 70 of about 3,358,181 (305)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells
Autophagy Reports, 2023 Venetoclax (VCX) is a BCL2 inhibitor approved for treating B cell-derived leukemia, including chronic lymphocytic leukemia (CLL). VCX’s role in apoptosis induction is well-defined, whereas its other mechanistic roles need to be clarified. Autophagy is an
Yongqiang Chen +6 more
doaj +1 more source
In Vitro Digestion of Peanut Skin Releases Bioactive Compounds and Increases Cancer Cell Toxicity
Antioxidants, 2023 Peanut skin is a rich source of bioactive compounds which may be able to reduce the risk factors associated with metabolic syndromes. This study aimed to characterize bio-compounds from peanut skin (Arachis hypogaea) and their bioactivity (antioxidant ...
Karina Cordeiro-Massironi +6 more
doaj +1 more source
Response of mouse epidermal cells to single doses of heavy-particles [PDF]
, 1972 The survival of mouse epidermal cells to heavy-particles has been studied In Vivo by the Withers clone technique. Experiments with accelerated helium, lithium and carbon ions were performed.
Leith, J. T. +2 more
core +1 more source
Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas. [PDF]
, 2017 Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous ...
Duvic, Madeleine +19 more
core +1 more source
Retinal degenerative diseases: role of dietary supplements in retinal health
Discover FoodRetinal degeneration is a progressive condition that affects the retina, the light-sensitive layer, and deteriorates the inner retinal cells that encompass retinal pigment epithelium, photoreceptors, and ganglion cells that are essential for eyesight ...
D. Mohan Kumar, Priti Talwar
doaj +1 more source
Nature Communications, 2019 Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting ...
Søs Grønbæk Holdgaard +27 more
doaj +1 more source
Structural Derivative Model for Tissue Radiation Response [PDF]
, 2017 By means of a recently-proposed metric or structural derivative, called scale-q-derivative approach, we formulate differential equation that models the cell death by a radiation exposure in tumor treatments.
Sotolongo-Costa, Oscar +1 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Active p21-Activated Kinase 1 Rescues MCF10A Breast Epithelial Cells from Undergoing Anoikis
Neoplasia: An International Journal for Oncology Research, 2005 The protein kinase, PAKi, is overexpressed in human breast cancer and may contribute to malignancy through induction of proliferation and invasiveness. In this study, we examined the role of PAKi in the survival of detached MCF10A breast epithelial cells
Raymond E. Menard +2 more
doaj +1 more source