Results 81 to 90 of about 2,251,671 (317)

Integrated Multi-omics Survival Analysis of Gynecologic and Breast Cancers [PDF]

, 2023
openThis study utilized a multi-omics approach, incorporating gene expression, methylation, copy number variation, and mutation data, to analyze the survival of patients with Breast Carcinoma and Gynecologic Cancers (Ovarian Serous Cystadenocarcinoma ...
ZOLFAGHARI, AMIN
core  

Nrf2 signaling and cell survival [PDF]

Toxicology and Applied Pharmacology, 2010
Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K, Niture, James W, Kaspar, Jun, Shen, Anil K, Jaiswal   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions

Biology Direct
Background As members of the nuclear receptor (NR) family of transcription factors, peroxisome proliferator-activated receptors (PPARs) regulate essential cellular processes, including lipid metabolism, glucose uptake, cell proliferation, and programmed ...
Pritha Saha, Palaniyandi Ravanan, Priti Talwar   +2 more
doaj   +1 more source

Study on TNFRSF mRNA Alterations and P53 Mutation in Head and Neck Squamous Cell Carcinoma

Journal of Orofacial Sciences, 2020
Introduction: Head and neck squamous cell cancer (HNSCC) is a common cancer worldwide. It has been associated with TP53 mutation and chronic inflammation. The control genes of inflammation, Tumor Necrosis Factor Receptor Superfamily (TNFRSF) in HNSCC has
Thavarajah Rooban, Immanuel Joseph, Selvan Preetha, Joshua Elizabeth, Umadevi Krishna Mohan Rao, Kannan Ranganathan   +5 more
doaj   +1 more source

TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons [PDF]

Ongoing, early-stage clinical trials illustrate the translational potential of human pluripotent stem cell (hPSC)-based cell therapies in Parkinson's disease (PD).
Mehta, Sanjoy, Koo, So Yeon, Chaudhry, Fayzan, Garippa, Ralph, Riessland, Markus, Kolisnyk, Benjamin, Saurat, Nathalie, Cho, Hyein S., Betel, Doron, Russo, Marco Vincenzo, Kim, Tae Wan, Studer, Lorenz   +11 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tumour-stromal interactions: Integrins and cell adhesions as modulators of mammary cell survival and transformation

, 2001
Stromal–epithelial interactions modulate mammary epithelial cell (MEC) growth and apoptosis by influencing cell adhesion and tissue organization. Perturbations in the mammary stroma and cell adhesion characterize breast tumors and underlie the altered ...
Chrenek, Micah A., Weaver, Valerie M., Wong, Paul   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides

, 2020
The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival. During growth, bacteria remodel their PG, releasing fragments that are predominantly reinternalized and recycled.
Dorr, Tobias, Cava, Felipe, Hernandez, Sara B.,, Waldor, Matthew K., Hernandez, Sara B., Cava, Felipe,   +5 more
core   +1 more source