Results 71 to 80 of about 8,088,933 (310)

Transforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation [PDF]

, 2001
In some situations, cell death in the nervous system is controlled by an interplay between survival factors and negative survival signals that actively induce apoptosis. The present work indicates that the survival of Schwann cells is regulated by such a
Whitfield, J, Meier, C, Parkinson, DB, Jeesen, KR, Dong, ZP, Mirsky, R, Bunting, H, Marie, H   +7 more
core  

Commentary: Surviving Terrorist Cells

Academic Medicine, 2009
The use of violent imagery, war metaphors, and the "survivor" persona in relation to cancer research and treatment are examined, as are consumer-driven approaches to "working toward a cure." The authors ask, what are the cultural and environmental trade-offs of these types of rhetoric?
Rebecca M, Herzig, Sarah Lochlann, Jain
openaire   +3 more sources

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Mathematical modelling of T cell homeostasis [PDF]

, 2010
T cell homeostasis describes the process through which the immune system regulates cell survival, proliferation, differentiation and death to maintain T cell numbers and diversity in a range of different conditions. The aim of this thesis is to better
Bains, I.K.
core  

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]

, 2013
CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon, T. Ueno, P. Fiorina, Baogong Zhu (399443), B. Zhu, Sayegh, Mohamed, Mohammed Javeed I. Ansari (399445), Antje Habicht (367049), A. Habicht, D'Addio, Francesca, Baogong Zhu, G. J. Freeman, Francesca D’Addio (289857), Mohammed Javeed I Ansari, Takuya Ueno (38813), Andrea Vergani (289866), Zhu, Baogong, F. D'Addio, Antje Habicht, M. H. Sayegh, Takuya Ueno, M. Clarkson, Clarkson, Michael, Habicht, Antje, D’Addio, Francesca, M. J. I. Ansari, Paolo Fiorina, Gordon J Freeman, Andrea Vergani, Mohammed Javeed, I. Ansari, Mohamed H. Sayegh (399444), Ansari, Mohammed Javeed I., Ueno, Takuya, Mohamed H Sayegh, Freeman, Gordon J., Michael Clarkson (399442), Fiorina, Paolo, Gordon J. Freeman (267166), Gordon J. Freeman, Vergani, Andrea, Mohamed H. Sayegh, Paolo Fiorina (251367), Michael Clarkson, A. Vergani, Sayegh, Mohamed H., Francesca D'Addio   +46 more
core   +2 more sources

A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1 [PDF]

, 2021
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GLUT3)
Darley-Usmar, Victor, Hjelmeland, Anita B, Benavides, Gloria A, Lasseigne, Brittany N, Tuy, Kaysaw, Gc, Sajina, Tran, Anh Nhat, Long, Ashlee, Augelli-Szafran, Corinne E, Zhang, Sixue, Jones, Amber B, Williford, Sarah E, Libby, Catherine J, Gordon, Emily R, Cooper, Sara J, Flavahan, William, Gordillo, Juan, Fisher, Jennifer L   +17 more
core   +1 more source

MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review

Cellular & Molecular Biology Letters
Mitochondria-associated membranes (MAMs) are tethering regions amid the membranes of the endoplasmic reticulum (ER) and mitochondria. They are a lipid raft-like structure occupied by various proteins that facilitates signal transduction between the two ...
A. Anjana Mohan, Priti Talwar
doaj   +1 more source

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

Frontiers in Physiology, 2019
Background and AimsActivation of the cAMP/Epac signalling stabilises endothelial barrier function. Moreover, its activation is accompanied by an activation of PI3K/Akt and MEK/ERK signalling in diverse cell types but their impact on endothelial barrier ...
Dursun Gündüz, Dursun Gündüz, Christian Troidl, Christian Troidl, Christian Tanislav, Christian Tanislav, Susanne Rohrbach, Christian Hamm, Muhammad Aslam, Muhammad Aslam   +9 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Nrf2 signaling and cell survival [PDF]

Toxicology and Applied Pharmacology, 2010
Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K, Niture, James W, Kaspar, Jun, Shen, Anil K, Jaiswal   +3 more
openaire   +2 more sources