Results 21 to 30 of about 3,358,181 (305)
Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host [PDF]
, 2017 Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival.
Clark, Jennifer +7 more
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Commentary: Surviving Terrorist Cells
Academic Medicine, 2009 The use of violent imagery, war metaphors, and the "survivor" persona in relation to cancer research and treatment are examined, as are consumer-driven approaches to "working toward a cure." The authors ask, what are the cultural and environmental trade-offs of these types of rhetoric?
Rebecca M, Herzig, Sarah Lochlann, Jain
openaire +3 more sources
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
Cell Reports, 2015 The mTORC1 complex is central to the cellular response to changes in nutrient availability. The signaling adaptor p62 contributes to mTORC1 activation in response to amino acids and interacts with TRAF6, which is required for the translocation of mTORC1 ...
Juan F. Linares +6 more
doaj +1 more source
Selective advantage for multicellular replicative strategies: A two-cell example [PDF]
, 2005 This paper develops a quasispecies model where cells can adopt a two-cell survival strategy. Within this strategy, pairs of cells join together, at which point one of the cells sacrifices its own replicative ability for the sake of the other cell.
Emmanuel Tannenbaum +2 more
core +1 more source
mTOR-Dependent Cell Survival Mechanisms [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called mTORC1 and mTORC2, which have distinct upstream regulatory signals and downstream substrates.
Hung, Chien-Min +3 more
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CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells
Frontiers in Molecular Neuroscience, 2017 Neuroblastoma is the most common solid extra cranial tumor in infants. Improving the clinical outcome of children with aggressive tumors undergoing one of the multiple treatment options has been a major concern.
Namrata Chaudhari +3 more
doaj +1 more source
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core +1 more source
Cell Transplantation, 1995 Tissue storage prior to intracerebral transplantation would represent a major advantage when conducting clinical transplantation trials in that the procurement of the embryonic donor tissue and the timing of neurosurgery could be planned more efficiently.
Eva M. Frodl +3 more
doaj +1 more source
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
core +3 more sources
Oncogenes in Cell Survival and Cell Death [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 The transforming effects of proto-oncogenes such as MYC that mediate unrestrained cell proliferation are countered by "intrinsic tumor suppressor mechanisms" that most often trigger apoptosis. Therefore, cooperating genetic or epigenetic effects to suppress apoptosis (e.g., overexpression of BCL2) are required to enable the dual transforming processes ...
Jake, Shortt, Ricky W, Johnstone
openaire +2 more sources