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Global availability of misoprostol
International Journal of Gynecology & Obstetrics, 2006Misoprostol is registered as a gastric ulcer drug in many middle to high income countries; it is also used 'off label' in these same countries to prevent and control PPH. Its ease of administration and stability in tropical climates make it an ideal drug for use in home births, as well as with Active Management of the Third Stage of Labor (AMTSL) in ...
Melodie Holden, Martha Campbell
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Overdosage of misoprostol in pregnancy
American Journal of Obstetrics and Gynecology, 1994We report the clinical course of a woman 31 weeks pregnant who ingested misoprostol (a prostaglandin E1 analog, Cytotek, used to prevent gastric ulcer) and trifluoperazine (Stelazine). Manifestations of toxicity included hypertonic uterine contraction with fetal death, hyperthermia, rhabdomyolysis, hypoxemia, respiratory alkalosis, and metabolic ...
G.Randall Bond, Art Van Zee
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Stability of misoprostol in suppositories
American Journal of Health-System Pharmacy, 2005Misoprostol is a prostaglandin E1 analogue originally marketed for use in the treatment of peptic ulcer disease. The practice of rectally administering misoprostol in doses of up to 1000 μg for obstetric use seems to be proliferating around the world.[1][1]–[4][2] Rectal administration ...
Joël Schlatter +4 more
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Obstetrics and Gynecology, 2017
OBJECTIVE To test the hypothesis that cervical ripening using a combination of misoprostol and a transcervical Foley bulb leads to delivery within a shorter time compared with misoprostol alone.
Zainab Al-ibraheemi +4 more
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OBJECTIVE To test the hypothesis that cervical ripening using a combination of misoprostol and a transcervical Foley bulb leads to delivery within a shorter time compared with misoprostol alone.
Zainab Al-ibraheemi +4 more
semanticscholar +1 more source
Misoprostol preclinical pharmacology
Digestive Diseases and Sciences, 1985Misoprostol, a synthetic derivative of prostaglandin E1, was tested and shown to be an effective gastric antisecretory agent against histamine-, pentagastrin-, and meal-stimulated acid secretion in dogs. Misoprostol reduced the volume of acid secretion as well as the hydrogen ion concentration. Misoprostol did not reduce gastric mucosal blood flow, nor
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Mifepristone-misoprostol medical abortion: home administration of misoprostol in guadeloupe
Contraception, 1999Mifepristone-misoprostol medical abortion promises to revolutionize reproductive health-care. Several simplifications of the standard three clinic visit regimen may be possible, however. Particularly in developing countries, access to the method can be greatly increased by eliminating the longest clinic visit.
Batya Elul +3 more
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Misoprostol for Womenʼs Health
Obstetrics & Gynecology, 2002To review published literature on misoprostol for women's health indications to provide a synthesis of available information and highlight areas in need of additional research.Studies were identified through searches of medical literature databases including MEDLINE, Cochrane Database, and Popline, in addition to a review of references from identified ...
Kelly Blanchard +5 more
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The European Journal of Contraception & Reproductive Health Care, 2011
One of the greatest imbalances between developed and developing countries is the risk of maternal death.
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One of the greatest imbalances between developed and developing countries is the risk of maternal death.
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Mifepristone+misoprostol vs. misoprostol alone for early medical abortion
Contraception, 2012Ngoc et al. [1], in their double-blind randomized placebocontrolled trial, show that mifepristone+misoprostol is more efficacious than misoprostol-only for early medical abortion. The study was conducted from August 2007 to March 2008 at a tertiary hospital in Vietnam. Using a misoprostol-only regimen, Ngoc et al. [1] report a complete abortion rate of
Thoai D. Ngo, Min Hae Park
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A comparison of tamoxifen and misoprostol to misoprostol alone for early pregnancy termination
Contraception, 1999A study was undertaken to determine whether the combination of oral tamoxifen and moistened misoprostol administered vaginally was superior to that of placebo and moistened misoprostol administered vaginally for elective termination of early pregnancies.A clinical trial was conducted with a study group of 150 healthy women with pregnancies of
Karen R. Meckstroth +3 more
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