Frontiers in Genetics, 2021 Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic effects in mammals on normal and high-fat diets (HFD). We previously reported that mifepristone blocks the negative effect on life span caused by mating in ...
Gary N. Landis +13 more
doaj +2 more sources
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors [PDF]
Molecular Oncology, 2016 The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds and
Lei Zhang +13 more
doaj +2 more sources
Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity [PDF]
Cancer Cell International, 2009 Background The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo.
Seidel Erin E +3 more
doaj +3 more sources
Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4 [PDF]
Cell & BioscienceBackground Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly defined ...
Jie Zhou +8 more
doaj +2 more sources
Biomedicines, 2023 The clinical use of mifepristone for medical abortions has been established in 1987 in France and since 2000 in the United States. Mifepristone has a limited medical period that lasts
Yu-Ting Su +7 more
doaj +1 more source
Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study [PDF]
, 2013 Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with ...
Chadarevian, Rita +4 more
core +11 more sources
Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity. [PDF]
PLoS ONE, 2013 The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have remained unclear.
Takeshi Hashimoto +7 more
doaj +1 more source
PLoS ONE, 2023 Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces midgut size ...
Gary N Landis +8 more
doaj +1 more source
International Journal of Hyperthermia, 2023 Objective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 ...
Hui Zhu +6 more
doaj +1 more source
Antitumor effect of mifepristone on human endometrial stromal cell line [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect of estrogen on endometrial cells. The aim of our study was to investigate and compare cytotoxic and apoptotic effects of mifepristone on human endometrial ...
Luković Jovan +7 more
doaj +1 more source