Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity. [PDF]
PLoS ONE, 2013 The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have remained unclear.
Takeshi Hashimoto +7 more
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Antitumor effect of mifepristone on human endometrial stromal cell line [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect of estrogen on endometrial cells. The aim of our study was to investigate and compare cytotoxic and apoptotic effects of mifepristone on human endometrial ...
Luković Jovan +7 more
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Mifepristone versus placebo to treat uterine myoma: a double-blind, randomized clinical trial
International Journal of Women's Health, 2013 Josep Lluis Carbonell Esteve,1 Rita Acosta,2 Yasmirian Pérez,2 Barbara Rodriguez,2 Isabel Seigler,2 Carlos Sanchez,2 Giuseppe Tomasi3 1Mediterránea Médica Clinic, Valencia, Spain; 2Eusebio Hernández Gynecology and Obstetrics ...
Esteve Carbonell JL +6 more
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Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4 [PDF]
Cell & BioscienceBackground Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly defined ...
Jie Zhou +8 more
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Mifepristone Improves Octreotide Efficacy in Resistant Ectopic Cushing’s Syndrome [PDF]
Case Reports in Endocrinology, 2016 A 30-year-old Caucasian man presented with severe Cushing’s syndrome (CS) resulting from ectopic adrenocorticotropin syndrome (EAS) from a metastatic pancreatic neuroendocrine tumor.
Andreas G. Moraitis, Richard J. Auchus
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Use of mifepristone in preparation of uterine cervix for delivery
Медицинский совет, 2013 The effectiveness of mifepristone in the preparation of cervix uteri to delivery was evaluated. Data on pregnancy, delivery and perinatal outcomes in 120 women with full-term births was analyzed. Mifepristone was most efficient in patients with Bishop's
V. A. Petrukhin +4 more
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Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells [PDF]
Molecular and Cellular Endocrinology, 2018 Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic treatment-induced obesity ...
Mario Navarro-Marquez +2 more
exaly +2 more sources
What motivates primary care providers to prescribe mifepristone medication abortion? Results of a qualitative investigation in Canada. [PDF]
BMC Prim CareMunro S, Ennis M, Wahl K, Williams A.
europepmc +2 more sources
Home use of mifepristone for medical abortion: a systematic review. [PDF]
BMJ Sex Reprod HealthBackground In many countries, persons seeking medical abortion with mifepristone followed by misoprostol can self-administer the second drug, misoprostol, at home, but self-administration of the first drug, mifepristone, is not allowed to the same extent.
Gemzell-Danielsson K +6 more
europepmc +2 more sources
Frontiers in Genetics, 2021 Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic effects in mammals on normal and high-fat diets (HFD). We previously reported that mifepristone blocks the negative effect on life span caused by mating in ...
Gary N. Landis +13 more
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