Results 21 to 30 of about 17,319 (251)

Direct Effects of Mifepristone on Mice Embryogenesis: An In Vitro Evaluation by Single-Embryo RNA Sequencing Analysis

Biomedicines, 2023
The clinical use of mifepristone for medical abortions has been established in 1987 in France and since 2000 in the United States. Mifepristone has a limited medical period that lasts
Yu-Ting Su, Jia-Shing Chen, Kuo-Chung Lan, Yung-Kuo Lee, Tian-Huei Chu, Yu-Cheng Ho, Cheng-Chun Wu, Fu-Jen Huang   +7 more
doaj   +1 more source

Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis

International Journal of Hyperthermia, 2023
Objective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 ...
Hui Zhu, Qimin Ma, Guoling Dong, Lijun Yang, Yang Li, Shumin Song, Yanchao Mu   +6 more
doaj   +1 more source

Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.

PLoS ONE, 2023
Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces midgut size ...
Gary N Landis, Hans S Bell, Oscar Peng, Brett Bognar, Andy Tong, Tomás D Manea, Hanmei Bao, Xianlin Han, John Tower   +8 more
doaj   +1 more source

Mifepristone increases the cytotoxicity of uterine natural killer cells by acting as a glucocorticoid antagonist via ERK activation. [PDF]

PLoS ONE, 2012
Mifepristone (RU486), a potent antagonist of progesterone and glucocorticoids, is involved in immune regulation. Our previous studies demonstrated that mifepristone directly augments the cytotoxicity of human uterine natural killer (uNK) cells.
Yuezhou Chen, Yan Wang, Yaling Zhuang, Feng Zhou, Lili Huang   +4 more
doaj   +1 more source

Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity

Frontiers in Aging, 2022
Mifepristone dramatically increases the life span of mated female Drosophila while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mated females ...
Gary N. Landis, Luke Riggan, Hans S. Bell, William Vu, Tianyi Wang, Ina Wang, Felicia I. Tejawinata, Sebastian Ko, John Tower   +8 more
doaj   +1 more source

Clinical management of patients with Cushing syndrome treated with mifepristone: consensus recommendations

Clinical Diabetes and Endocrinology, 2020
Background While surgery is the first-line treatment for patients with endogenous hypercortisolism (Cushing syndrome [CS]), mifepristone has been shown to be a beneficial medical treatment option, as demonstrated in the SEISMIC (Study of the Efficacy and
David R. Brown, Honey E. East, Bradley S. Eilerman, Murray B. Gordon, Elizabeth E. King, Laura A. Knecht, Brandon Salke, Susan L. Samson, Kevin C. J. Yuen, Hanford Yau   +9 more
doaj   +1 more source

Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Mifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a single dose in conjunction with misoprostol, mifepristone is used to induce medical abortion.
Taylor A. Ault, David R. Braxton, Rebecca A. Watson, Alan O. Marcus, Tse-Ling Fong   +4 more
doaj   +1 more source

Mifepristone Directly Disrupts Mouse Embryonic Development in Terms of Cellular Proliferation and Maturation In Vitro

Toxics, 2021
Mifepristone (RU-486), a synthetic steroid with potent antiprogestogen and anti-glucocorticoid properties, has been widely used in clinical practice. Its effect on the endometrium, ovary, and fallopian tube has been well reported in many human and animal
Yu-Ting Su, Jia-Shing Chen, Yi-Ru Tsai, Kuo-Chung Lan, Cheng-Chun Wu, Fu-Jen Huang   +5 more
doaj   +1 more source

The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy

BMC Pharmacology and Toxicology, 2022
Background As a progesterone receptor antagonist, mifepristone combined with misoprostol is widely used to terminate early pregnancy in clinical practice.
Fei Tian, Hua Han, Ligang Jia, Junqin Zhang, Zhaoping Chu, Jie Li, Yuan Zhang, Ping Yan   +7 more
doaj   +1 more source

Pharmacist direct dispensing of mifepristone for medication abortion in Canada: a survey of community pharmacists

BMJ Open, 2022
Introduction Pharmacists were acknowledged as the most appropriate healthcare professional to dispense mifepristone for medication abortion shortly after the prescription therapy became available in January 2017 in Canada.Objective We aimed to identify ...
Wendy V Norman, Sarah Munro, Judith A Soon, Enav Z Zusman   +3 more
doaj   +1 more source