Results 231 to 240 of about 620,845 (342)

Bringing Trial Activities to Participants—The Trials@Home RADIAL Proof‐of‐Concept Trial Investigating Decentralization of Trials

Clinical Pharmacology &Therapeutics, EarlyView.
The interest in trials in which activities are being moved to the participants' direct environment, that is, decentralized, has increased in recent years, but limited research has been conducted into the feasibility and acceptability of such approaches.
Mira G.P. Zuidgeest, Megan Heath, Bart Lagerwaard, Danny R. van Weelij, Linda Rutgrink, Sten Hanke, Tea Vedenkannas, Taru Kosonen, Stefania Collamati, Jaime Fons‐Martínez, Duco Veen, Helga Gardarsdottir, Isla S. Mackenzie, Sabine Dupont, Diederick E. Grobbee, on behalf of the Trials@Home consortium   +15 more
wiley   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

The Feasibility and Quality of the European Prescribing Exam: An International Multicenter Pilot Study Among 3109 Medical Students From 16 Medical Schools

Clinical Pharmacology &Therapeutics, EarlyView.
The WHO Global Patient Safety Challenge “Medication Without Harm” emphasizes the need to improve doctors' prescribing competence. Junior doctors are particularly at risk of prescribing errors due to inadequate training. To address this, the European Prescribing Exam was developed to standardize and improve clinical pharmacology and therapeutics (CPT ...
Erik M. Donker, Joost D. Piët, David J. Brinkman, Milan C. Richir, Paraskevi Papaioannidou, Robert Likic, Emilio J. Sanz, Thierry Christiaens, João N. Costa, Fabrizio De Ponti, Ylva Böttiger, Cornelis Kramers, Michiel A. van Agtmael, Jelle Tichelaar, on behalf of the Erasmus+ consortium EuroPE+ and the EACPT Education Working Group, Emilio Sanz, Carla Sans, Ellen van Leeuwen, Haithem Chtioui, Joao Costa, Jitka Rychlickova, Lorena Dima, Romaldas Maciulaitis, Marc Labriffe, Bogdan Tamba, Michiel van Agtmael, Erik Donker   +26 more
wiley   +1 more source

Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof‐of‐Concept Trial

Clinical Pharmacology &Therapeutics, EarlyView.
While decentralized clinical trials (DCTs) hold great promise for improving trial accessibility and efficiency, the effective deployment of DCT elements requires robust technological infrastructure and careful system integration. Although several innovative technologies are now available for implementing DCT elements, most existing setups integrate ...
Sten Hanke, Dimitrios Giannikopoulos, Bernhard Neumayer, Tea Vedenkannas, Robert Davey, Lampros Mpaltadoros, Brian Guthrie, Rebecca Jackson, Bart Lagerwaard, Mira Zuidgeest, on behalf of the Trials@Home consortium   +10 more
wiley   +1 more source

The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants—Insights from the Trials@Home RADIAL Proof‐of‐Concept Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Decentralized clinical trials (DCTs), which move trial activities to participants' homes or direct surroundings, offer potential advantages over conventional site‐based trials through reduced participant burden and improved accessibility. The direct‐to‐participant (DtP) delivery of investigational medicinal products (IMPs) and other study materials and
Megan Heath, Amos J. de Jong, Shaun Magorrian‐Spence, Chao Jin, Danny R. van Weelij, Lucas Pagnier, Yvonne van Rijswick, Volker Haufe, Bart Lagerwaard, Mira G. P. Zuidgeest, on behalf of the Trials@Home consortium   +10 more
wiley   +1 more source

Selecting and Preparing Clinical Sites for the Successful Conduct of Decentralized Clinical Trial Activities–Findings From the Trials@Home RADIAL Proof‐of‐Concept Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Decentralized clinical trials (DCTs) offer opportunities to improve trial accessibility, participant convenience, and efficiency, yet may pose significant operational challenges for clinical trial sites. This paper presents the operational insights gained from selecting, training, and supporting clinical sites within the RADIAL proof‐of‐concept trial ...
Katarzyna Lipinska, Danny van Weelij, Bart Lagerwaard, Linda Rutgrink, Eduard Vardianu, Petra Naster, Lina Pérez‐Breva, Paul Bodfish, Megan Heath, Yvonne van Rijswick, Diederick E. Grobbee, Mira G.P. Zuidgeest, on behalf of the Trials@Home consortium   +12 more
wiley   +1 more source

Secondary schools' preparation for roll‐out of Curriculum for Wales: Case studies of approaches to health and well‐being in the context of national education system reform

The Curriculum Journal, EarlyView.
Abstract Schools are increasingly positioned as key settings for promoting health behaviours and well‐being. Curriculum for Wales (CfW) represents major national reform of the Welsh education system, placing unprecedented focus on health and well‐being for learners in compulsory education (aged 3–16).
Rochelle Embling, Cara O'Donnell, Graham Moore, Sara Jayne Long   +3 more
wiley   +1 more source

The Relationship Between Therapeutic Alliance, Early Symptom Change, and Outcome Among In‐Patients With Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Therapeutic alliance (TA) is an important process variable, evidence suggesting its influence on treatment outcome across several mental disorders. Yet, its role in treating anorexia nervosa (AN) remains under‐examined. Previous research has yielded heterogeneous results, indicating a complex relationship between TA, early change ...
Janina Werz, Brunna Tuschen‐Caffier, Ulrich Voderholzer   +2 more
wiley   +1 more source

A Historical Cohort Comparison After Inpatient Admission for Adolescents With Anorexia Nervosa: Feasibility of Virtual Group Therapy

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Access to follow‐up care after a medical admission for adolescents with anorexia nervosa (AN) is important; yet access can be delayed or unavailable. This study assessed the feasibility and acceptability of a supplemental virtual 8‐week outpatient group therapy program following inpatient care. A secondary aim explored the outpatient
Elizabeth V. Franklin, Margaret Mathias, Rachel Wolfe, Duc T. Nguyen, Drusilla M. Rosales, Sofia Pedroza, Albert C. Hergenroeder, Constance M. Wiemann   +7 more
wiley   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source