Results 131 to 140 of about 1,714,069 (326)
An equivalence result for moment equations when data are missing at random
Statistical Theory and Related Fields, 2019 We consider general statistical models defined by moment equations when data are missing at random. Using the inverse probability weighting, such a model is shown to be equivalent with a model for the observed variables only, augmented by a moment ...
Marian Hristache, Valentin Patilea
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Doubly weighted M-estimation for nonrandom assignment and missing outcomes
Journal of Causal InferenceThis article proposes a class of M-estimators that double weight for the joint problems of nonrandom treatment assignment and missing outcomes. Identification of the main parameter of interest is achieved under unconfoundedness and missing at random ...
Negi Akanksha
doaj +1 more source
Positive-Unlabeled Learning in Implicit Feedback from Data Missing-Not-At-Random Perspective
EntropyThe lack of explicit negative labels issue is a prevalent challenge in numerous domains, including CV, NLP, and Recommender Systems (RSs). To address this challenge, many negative sample completion methods are proposed, such as optimizing sample ...
Sichao Wang, Tianyu Xia, Lingxiao Yang
doaj +1 more source
Bayesian nonparametric generative models for causal inference with\n missing at random covariates [PDF]
, 2017 Jason Roy +5 more
openalex +1 more source
Robust weighted fusion Kalman estimators for systems with uncertain noise variances, multiplicative noises, missing measurements, packets dropouts and two‐step random measurement delays [PDF]
, 2023 Chunshan Yang +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source