Results 91 to 100 of about 1,808,699 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Missing Data as Political Force

open access: yesDIID
In today’s society, data shapes how states and corporations treat people. It is closely connected to questions of economic, cultural and political representation and equality.
Max Frischknecht
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Note on Missing Data Effects on the Hausman (1978) Simultaneity Test: Some Monte Carlo Results. [PDF]

open access: yes
This short paper demonstrates the effects of using missing data on the power of the well-known Hausman (1978) test for simultaneity in structural econometric models.
Konstantinos Tsagarakis   +1 more
core  

Stories Across Missing Data Typologies

open access: yesDIID
The cases presented here are introduced as representative examples of the typologies outlined in the curatorial framework. The aim of this Stories section is to explore alternative formats that deal with absence of data in different ways and in order to
Simona Colitti
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Semiparametric Regression Analysis under Imputation for Missing Response Data [PDF]

open access: yes
We develop inference tools in a semiparametric regression model with missing response data. A semiparametric regression imputation estimator, a marginal average estimator and a (marginal) propensity score weighted estimator are defined.
Qihua Wang   +2 more
core  

Imputation and Missing Indicators for Handling Missing Longitudinal Data: Data Simulation Analysis Based on Electronic Health Record Data

open access: yesJMIR Medical Informatics
BackgroundMissing data in electronic health records are highly prevalent and result in analytical concerns such as heterogeneous sources of bias and loss of statistical power.
Molly Ehrig   +4 more
doaj   +1 more source

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