Results 111 to 120 of about 1,808,699 (310)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Taking "Don't Knows" as Valid Responses: A Complete Random Imputation of Missing Data [PDF]
Incomplete data is a common problem of survey research. Recent work on multiple imputation techniques has increased analysts' awareness of the biasing effects of missing data and has also provided a convenient solution.
Martin Kroh
core
Modeling correlated Missing Data [PDF]
Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-Tiğāriyyaẗ, 2017 samy Abdelmoez
doaj +1 more source
Impact of Missing Data on Data Quality in Social Research
Соціологічні студіїMissing data is a common issue in quantitative social research that negatively affects the data quality. This article explores the consequences of missing data, outlining the potential issues it may pose and emphasizing the importance of properly ...
Yaroslav Kostenko
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Low-rank matrix approximation with weights or missing data is NP-hard [PDF]
Weighted low-rank approximation (WLRA), a dimensionality reduction technique for data analysis, has been successfully used in several applications, such as in collaborative filtering to design recommender systems or in computer vision to recover ...
GILLIS, Nicolas, GLINEUR, François
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Compensating for Missing Data from Longitudinal Studies Using WinBUGS
Missing data is a common problem in survey based research. There are many packages that compensate for missing data but few can easily compensate for missing longitudinal data.
Gita Mishra +3 more
core
, 2015 Longitudinal electronic health records are a valuable resource for research because they contain information on many patients over long follow-up periods.
Welch, CA
core