Results 171 to 180 of about 1,808,699 (310)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EVALUATING ALTERNATIVE METHODS OF DEALING WITH MISSING OBSERVATIONS - AN ECONOMIC APPLICATION

This paper compares methods to remedy missing value problems in survey data. The commonly used methods to deal with this issue are to delete observations that have missing values (case-deletion), replace missing values with sample mean (mean imputation),
Onozaka, Yuko
core  

The influence of life course socioeconomic position on cognitive function and cognitive decline in older age: the impact of missing data

, 2012
Cognitive function has been associated with many physical and mental health conditions, as well as mortality. Cognitive decline is one aspect of ageing that causes anxiety among the general population.
Landy, R
core  

Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring. [PDF]

Diabetes Care
Kok N, Williamson WT, Lee JM, Gaynanova I.   +3 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Generalized canonical correlation analysis with missing values

Two new methods for dealing with missing values in generalized canonicalcorrelation analysis are introduced. The first approach, which does notrequire iterations, is a generalization of the Test Equating method availablefor principal component analysis ...
Velden, M. van de, Takane, Y.
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Imputation and estimation under nonignorable nonresponse for household surveys with missing covariate information

, 2010
In this paper we develop and apply new methods for handling not missing at random (NMAR) nonresponse. We assume a model for the outcome variable under complete response and a model for the response probability, which is allowed to depend on the outcome ...
Pfeffermann, Danny, Sikov, Anna
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Addressing nonignorable missing data and heterogeneity in prognostic biomarker assessment. [PDF]

Stat Methods Med Res
Huang X, Li R, Ning J, For The Alzheimer's Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A comparative analysis of soft computing techniques used to estimate missing precipitation records

, 2012
Estimation of missing precipitation records is one of the most important tasks in hydrological and environmental study. The efficiency of hydrological and environmental models is subject to the completeness of precipitation data. This study compared some
Wong, K.W., Fung, Chun Che, Fung, C.C., Wong, Kok Wai, Kajornrit, Jesada, Kajornrit, J.   +5 more
core