Results 91 to 100 of about 1,718,863 (277)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analyzing the changing gender wage gap based on multiply imputed right censored wages [PDF]
"In order to analyze the gender wage gap with the German IAB-employment sample we have to solve the problem of censored wages at the upper limit of the social security system. We treat this problem as a missing data problem.
Gartner, Hermann, Rässler, Susanne
core
American Journal of Orthodontics and Dentofacial Orthopedics, 2022 Tra My Pham +2 more
openaire +3 more sources
The Efficiency of Missing at Random Planned Missing Designs
MathematicsPlanned Missing Designs (PMDs) allow for different sets or patterns of variables to be collected from sample units. While the typical motivation for PMDs is to manage respondent burden, they can also reduce data collection costs and provide flexibility in meeting reliability requirements for key survey outputs.
David G. Steel, James Chipperfield
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Messy Data Modelling in Health Care Contingent Valuation Studies [PDF]
This study addresses the complexity in modeling contingent valuation surveys with true zeros and non-ignorable missing responses including “don’t knows†and protest responses. An endogenous switching tobit model is specified to simultaneously estimate
Kostas Mavromaras +2 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Missing ordinal covariates with informative selection [PDF]
This paper considers the problem of parameter estimation in a model for a continuous response variable y when an important ordinal explanatory variable x is missing for a large proportion of the sample.
Alfonso Miranda, Sophia Rabe-Hesketh
core
The impact of partially missing communities~on the reliability of centrality measures
, 2017 Network data is usually not error-free, and the absence of some nodes is a very common type of measurement error. Studies have shown that the reliability of centrality measures is severely affected by missing nodes.
A Rezvanian +26 more
core +1 more source