Results 51 to 60 of about 549,387 (258)

Generating Synthetic Missing Data: A Review by Missing Mechanism

IEEE Access, 2019
The performance evaluation of imputation algorithms often involves the generation of missing values. Missing values can be inserted in only one feature (univariate configuration) or in several features (multivariate configuration) at different ...
Miriam Seoane Santos, Ricardo Cardoso Pereira, Adriana Fonseca Costa, Jastin Pompeu Soares, Joao Santos, Pedro Henriques Abreu   +5 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Two-stage multiple imputation with a longitudinal composite variable

BMC Medical Research Methodology
Background Missing data are common in longitudinal studies. Multiple imputation (MI) is widely used to handle missing data. However, most of the MI methods assume various missing data types as missing at random (MAR) in imputation.
Xuzhi Wang, Martin G. Larson, Chunyu Liu
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Exploring the impact of missing data on maternal tobacco program results: an analysis of self-efficacy on smoking cessation

BMC Public Health
Background Tobacco use is a major contributor to chronic illnesses worldwide, leading to significant morbidity and mortality. Effective tobacco cessation programs are crucial in reducing the health risks associated with smoking.
Mengting Zhao, Benjamin Langworthy
doaj   +1 more source

A survey on missing data in machine learning

Journal of Big Data, 2021
Machine learning has been the corner stone in analysing and extracting information from data and often a problem of missing values is encountered. Missing values occur because of various factors like missing completely at random, missing at random or ...
Tlamelo Emmanuel, Thabiso Maupong, Dimane Mpoeleng, Thabo Semong, Banyatsang Mphago, Oteng Tabona   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A systematic approach towards missing lab data in electronic health records: A case study in non‐small cell lung cancer and multiple myeloma

CPT: Pharmacometrics & Systems Pharmacology, 2023
Real‐world data derived from electronic health records often exhibit high levels of missingness in variables, such as laboratory results, presenting a challenge for statistical analyses.
Arjun Sondhi, Janick Weberpals, Prakirthi Yerram, Chengsheng Jiang, Michael Taylor, Meghna Samant, Sarah Cherng   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source