Results 91 to 100 of about 260,158 (259)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Dynamic mechanical response of unsaturated beach sand under confined one-dimensional compression

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
This study investigates the dynamic mechanical behavior of unsaturated beach sand under high-strain-rate loading (300–1000 s⁻1) using a modified Split-Hopkinson Pressure Bar (SHPB) system with passive confinement.
Jian’an Wu, Linjian Ma, Hansheng Geng, Yuetang Zhao, Zeng Li, Jicheng Liu, Lu Dong   +6 more
doaj   +1 more source

Automated Generation of Geometric FE Models for Timber Structures Using 3D Point Cloud Data

Buildings
Manual geometric modeling of timber structures is time-intensive and error-prone, impeding efficient structural analysis. To overcome this limitation, this study develops an automated framework for the rapid generation of 3D geometric finite element (FE)
Lin Chen, Liufang Jiang, Haibei Xiong
doaj   +1 more source

Mitigation and Mitigation Banking

Journal of the Japanese Society of Revegetation Technology, 1997
MORIMOTO, Yukihiro, MURATA, Tatsuo, WAKAI, Masaki   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Opportunities and Challenges Faced by the Basic Marine Ecological Early Warning Monitoring Institutions

Haiyang Kaifa yu guanli
With the intensification of global climate change and the increasing frequency of human marine activities, the marine ecosystem is facing unprecedented pressure.
LIU Xinjie, LIU Liang, XU Yushan, ZHANG Xinxin, LI Ying   +4 more
doaj  

Causes of the Outer Spiral Rainbands in Typhoon Yagi （ 2018） in Shandong Province of China

Gaoyuan qixiang
On August 14， 2018， Typhoon Yagi （2018） moved northward and impacted Shandong Province of China， resulting in widespread rainstorm and heavy rainstorm.The total rainfall caused by the typhoon in Shandong presents a round-shaped distribution.Specifically，
Chunyan SHENG, Sudan FAN, Qiaona QU, Shijun LIU, Wengang ZHU   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source