Results 81 to 90 of about 1,243,430 (291)

Experimental and Numerical Study on the Seismic Performance of Base-Suspended Pendulum Isolation Structure

Buildings
This paper proposes a novel suspended seismic structure system called Base-suspended Pendulum Isolation (BSPI) structure. The BSPI structure can isolate seismic action and reduce structural seismic response by hanging the structure with hanger rods set ...
Liang Lu, Lei Wang, Wanqiu Xia, Minghao Yin   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reducing Global Warming: The Potential of Organic Agriculture [PDF]

, 2012
Climate change mitigation is urgent, and adaptation to climate change is crucial, particularly in agriculture, where food security is at stake. Agriculture, currently responsible for 20-30% of global greenhouse gas emissions (counting direct and indirect
Davis, Joan, Dytrtová, Karolína, Gattinger, Andreas, Lampkin, Nic, Müller, Adrian, Niggli, Urs, Olesen, Joergen, Smith, Laurence   +7 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Study on the Community Structure and Diversity of Zooplankton in Dingzi Bay by Using Mathematical and Intelligent Analysis Tools [PDF]

E3S Web of Conferences
In order to know the community structure and diversity of zooplankton in Dingzi Bay, based on the investigation data in April 2024(spring), the species composition, dominant species, community structure and the correlation between species diversity and ...
Zhang Liang, Huang Juan, Liu Yumeng, Gu Xueji, Zhao Chuanting   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Preliminary Investigations and Analysis of Social Public's Awareness of Rip Currents

Haiyang Kaifa yu guanli
Hainan Province is characterized by deep water, high winds and waves, and a large number of rip currents along the coastal beaches, resulting in frequent drowning accidents.
ZHANG Wanru, ZHANG Yao, XU Zhenshan, WU Congyu, FU Xinyi, GUO Xianze, WU Jiangyue   +6 more
doaj  

Lightweight ultra-high performance concrete prepared with the waste fraction of sintered shale pottery sand: preparation, mechanical properties, and material selection method

Low-Carbon Materials and Green Construction
To address the high construction difficulty and cost resulting from the heavy self-weight of concrete-filled steel tube (CFST) skeletons in the construction of long-span arch bridges, as well as the ineffective utilization of 0–3 mm waste fraction of ...
Jian Yang, Xiaolong Li, Xilun Ma, Xiangguo Wu, Junwei Luo, Kai Luo   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source