Results 61 to 70 of about 281,174 (219)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Study on the surge formula system of typical dangerous rock mass collapse with different instability modes

Zhongguo dizhi zaihai yu fangzhi xuebao
The collapse of high and steep dangerous rock in the gorge area produces huge surge hazards, which seriously endangers the safety of waterways and scenic spots. However, the systematic research on the surge caused by perilous rock collapse is not enough,
Jie ZHANG, Bolin HUANG, Xingchen DONG, Qiuwang LI   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Recent Building Exposures in Banda Aceh-Indonesia Based on A 1000-Year Return Period Tsunami Hazard Analysis [PDF]

E3S Web of Conferences
The 2004 Indian Ocean (Aceh) Tsunami caused massive damage to buildings and infrastructure in coastal Aceh, Indonesia. Because Aceh lies in an active fault zone, the potential for another earthquake capable of triggering a major tsunami remains high ...
Ayumi Waznah, Syamsidik Syamsidik, Idris Yunita, Agustina Sylvia, Tursina   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Experimental and Numerical Study on the Seismic Performance of Base-Suspended Pendulum Isolation Structure

Buildings
This paper proposes a novel suspended seismic structure system called Base-suspended Pendulum Isolation (BSPI) structure. The BSPI structure can isolate seismic action and reduce structural seismic response by hanging the structure with hanger rods set ...
Liang Lu, Lei Wang, Wanqiu Xia, Minghao Yin   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Preliminary Investigations and Analysis of Social Public's Awareness of Rip Currents

Haiyang Kaifa yu guanli
Hainan Province is characterized by deep water, high winds and waves, and a large number of rip currents along the coastal beaches, resulting in frequent drowning accidents.
ZHANG Wanru, ZHANG Yao, XU Zhenshan, WU Congyu, FU Xinyi, GUO Xianze, WU Jiangyue   +6 more
doaj