Results 51 to 60 of about 281,174 (219)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Wind Data Quality Control Algorithm Utilizing Deep Learning-Based Association Test Rules

Journal of Marine Science and Engineering
Harnessing the powerful learning and modeling capabilities of artificial intelligence, this study introduces a deep learning-driven wind data quality control algorithm that employs correlation verification rules.
Ruidi Ma, Song Gao, Fan Jiang, Bo Yu, Haoqiang Tian, Yanchen Song, Yong Ge, Dianjun Ren, Chenxu Wang   +8 more
doaj   +1 more source

Why Seismic Intensity Measure Matters and How ASFRAVA-B Advances It [PDF]

E3S Web of Conferences
This paper presents ASFRAVA-B, an open-source desktop platform that generates fragility and vulnerability curves within a single graphical interface. Using a two-story reinforced concrete infilled frame, we compare three scalar Intensity Measures (IMs ...
Ulza Adrian, Puspitasari Rizka, Khalqillah Aulia   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Theoretical Study on a Cable-Bracing Inerter System for Seismic Mitigation

Applied Sciences, 2019
In this paper, cables are proposed to connect the inerter and main frame for translation-to-rotation conversion, i.e., the cable-bracing inerter system (CBIS), with a magnified mass and enhanced damping effect.
Liyu Xie, Xinlei Ban, Songtao Xue, Kohju Ikago, Jianfei Kang, Hesheng Tang   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Predicting the current fishable habitat distribution of Antarctic toothfish (Dissostichus mawsoni) and its shift in the future under climate change in the Southern Ocean [PDF]

PeerJ
Global warming continues to exert unprecedented impacts on marine habitats. Species distribution models (SDMs) are proven powerful in predicting habitat distribution for marine demersal species under climate change impacts.
Jie Liu, Ancheng Zhu, Xitao Wang, Xiangjun Zhou, Lu Chen   +4 more
doaj   +2 more sources

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source