Results 121 to 130 of about 591,098 (317)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Generation and characterization of genetically encoded fluorescent probes to visualize mitochondria-endoplasmic reticulum contact sites. [PDF]
, 2023 openEndoplasmic reticulum (ER) physically contacts mitochondria via its specialized subdomain called mitochondria-associated membranes (MAMs) at sites of mitochondria-ER contacts (MERCs).
MISCIA, AURELIA
core
SensorsThe continuous monitoring of oxygen saturation (SpO2) and respiratory rates (RRs) are major clinical issues in many cardio-respiratory diseases and have been of tremendous importance during the COVID-19 pandemic.
Charles Evrard +7 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Targeting mitochondria and metastasis: recent advances and perspectives. [PDF]
, 2014 Despite growing interest in cancer metabolism, knowledge of the metabolic control of tumor metastasis is still limited. Through the generation of cancer cell models characterized by increased invasive and metastatic potential, we identified a ...
Targeting Mitochondria 5th congress, World Mitochondria Society +1 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Mitochondria-free presynaptic boutons have increased cytoplasmic Ca2+ during repetitive stimulation. [PDF]
, 2016 (A) Mitochondria-occupied and -free presynaptic Ca2+ dynamics were monitored using vGlut1-GCaMP5G and mito-mTagBFP in axons of cultured cortical neurons following ex utero electroporation at E15.5 and imaged at 15–17 DIV.
Seok-Kyu Kwon (3151941) +5 more
core +1 more source
SensorsIn the last few decades, there has been an ongoing transformation of our healthcare system with larger use of sensors for remote care and artificial intelligence (AI) tools.
Marie Geny +3 more
doaj +1 more source