Results 121 to 130 of about 902,846 (308)

Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium [PDF]

Funding Information: This work was funded by the MRC (MR/X020827/1) awarded to T.B., Wellcome Trust (212216/Z/18/Z) awarded to C.E.F., National Institutes of Health (RO1\u2019s AG058171, AG081981, EY034309) awarded to B.A.B and Diabetes UK fellowship (23/
De Rossi, Giulia, Bruce A. Berkowitz, Luthert, Philip J., Burgoyne, Thomas, Miguel C. Seabra, Berkowitz, Bruce A., Futter, Clare E., Thomas Burgoyne, Matilde V. Neto, C Seabra, Miguel, Clare E. Futter, Giulia De Rossi, Neto, Matilde V., Philip J. Luthert   +13 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Accuracy of Rhythm Diagnostic Systems’ MultiSense^® in Detection of Arterial Oxygen Saturation and Respiratory Rate During Hypoxia in Humans: Effects of Skin Color and Device Localization

Sensors
The continuous monitoring of oxygen saturation (SpO2) and respiratory rates (RRs) are major clinical issues in many cardio-respiratory diseases and have been of tremendous importance during the COVID-19 pandemic.
Charles Evrard, Amina El Attaoui, Cristina Pistea, Irina Enache, Mark Marriott, Louis Mayaud, Anne Charloux, Bernard Geny   +7 more
doaj   +1 more source

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Nature Neuroscience, 2019
In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here we show that the expression of neurotoxic proteins associated with these diseases in microglia alone is ...
A. U. Joshi, Paras S. Minhas, SA Liddelow, B. Haileselassie, K. Andreasson, G. Dorn, D. Mochly-Rosen   +6 more
semanticscholar   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]

, 1975
Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Oda, Takuzo, Inaba, Kozo
core   +1 more source

Liability of Health Professionals Using Sensors, Telemedicine and Artificial Intelligence for Remote Healthcare

Sensors
In the last few decades, there has been an ongoing transformation of our healthcare system with larger use of sensors for remote care and artificial intelligence (AI) tools.
Marie Geny, Emmanuel Andres, Samy Talha, Bernard Geny   +3 more
doaj   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Mitochondria in the Nuclei of Rat Myocardial Cells

, 2020
Electron microscopic study of cardiomyocytes taken from healthy Wistar and OXYS rats and naked mole rats (Heterocephalus glaber) revealed mitochondria in nuclei that lacked part of the nuclear envelope.
Irina M. Vangely, Vangely, IM, Vays, VB, Skulachev, Vladimir P., Eldarov, CM, Hildebrandt, Thomas Bernd, Plotnikov, Egor, Skulachev, VP, Sheval, Eugene V., Natalia G. Kolosova, Eldarov, Chupalav M., Lora E. Bakeeva, Holtze, Susanne, Eugene V. Sheval, Vangely, Irina M., Bakeeva, Lora E., Hildebrandt, TB, Holtze, S, Vladimir P. Skulachev, Valeriya B. Vays, Zorov, DB, Chupalav M. Eldarov, Kolosova, NG, Sheval, EV, Kolosova, Nataliya G, Dmitry B. Zorov, Vasily A. Popkov, Zorov, Dmitry B., Plotnikov, EY, Bakeeva, LE, Egor Y. Plotnikov, Thomas B. Hildebrandt, Susanne Holtze, Popkov, VA, Vays, Valeriya B.   +34 more
core   +1 more source

Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy [PDF]

, 2018
PGAM5 is a unique type of protein phosphatase that exists in mitochondria. It has been shown to exist in the inner mitochondrial membrane through its transmembrane domain and to be cleaved within the transmembrane domain upon mitochondrial dysfunction ...
Ishikawa, Hayate, Yokozeki, Masashi, Furuoka, Mana, Tanimura, Susumu, Yamaguchi, Ayane, Takeda, Kohsuke, Matsuda, Noriyuki   +6 more
core   +1 more source