Results 161 to 170 of about 902,846 (308)
Advanced Science, EarlyView.A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang +11 more
wiley +1 more source
, 2016 (A) Presynaptic release properties at mitochondria-associated and -free boutons were monitored using synaptophysin-pHluorin and mito-mTagBFP in cultured neurons at 15–17 DIV. (B) Representative image of sypH peak value following 20 AP at 10 Hz.
Seok-Kyu Kwon (3151941) +5 more
core +1 more source
Frontiers in Cell and Developmental BiologyMitochondria play a central role in cellular bioenergetics, being major counterparts in ATP production and thus in the maintenance of cells, but they are also key mediators of different types of cell death (apoptosis, necroptosis, ferroptosis, etc.) and ...
Patrice X. Petit
doaj +1 more source
Mitochondria, oxidants, and aging.
Cell, 2005 R. Balaban, S. Nemoto, T. Finkel
semanticscholar +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Targeting mitochondria and metastasis: recent advances and perspectives.
, 2014 Despite growing interest in cancer metabolism, knowledge of the metabolic control of tumor metastasis is still limited. Through the generation of cancer cell models characterized by increased invasive and metastatic potential, we identified a ...
Targeting Mitochondria 5th congress, World Mitochondria Society +1 more
core
Mitochondria-Targeting Thermosensitive Initiator with Enhanced Anticancer Efficiency
, 2019 As one of the most important organelles in cells, the mitochondrion has been reported to exhibit higher temperatures and is vulnerable to free radicals, especially in cancer cells.
Han Cheng (475615) +13 more
core +1 more source
Advanced Science, EarlyView.GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han +16 more
wiley +1 more source
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source