Results 321 to 330 of about 1,007,169 (424)

The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus

Advanced Science, EarlyView.
Large‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia‐Shigella in patients with T2DM‐related‐ASCVD, which correlates with their
Yao‐Yuan Zhang, Song‐Tao Chen, Gang Chen, Le Zhou, Guo‐Liang Zhou, Xin‐Yuan Yu, Long Yuan, Wei‐Qian Deng, Zhen‐Bo Wang, Jing Li, Yi‐Fu Tu, Da‐Wei Zhang, Yuan li, Abdul Sammad, Xiao Zhu, Kai Yin   +15 more
wiley   +1 more source

Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies. [PDF]

J Transl Med
Chen C, Dai G, Fan M, Wang X, Niu K, Gao W.   +5 more
europepmc   +1 more source

The enzymatic function of mitochondria in the germination of cereals

, 1927
E. S. Horning, A. H. K. Petrie
openalex   +1 more source

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) can induce dysfunction in adrenal steroid synthesis in adult male offspring. This study demonstrate that the mechanism is associated with the upregulation of fetal adrenal cholesterol 27 hydroxylase (CYP27A1)promoter region histone 3 lysine 27 acetylation (H3K27ac) levels and expression mediated by PDE through the ...
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang   +7 more
wiley   +1 more source

Hypertrophic Cardiomyopathy Through the Lens of Mitochondria. [PDF]

Biomedicines
Kirichenko TV, Zhivodernikov IV, Kozlova MA, Markin AM, Sinyov VV, Markina YV.   +5 more
europepmc   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction. [PDF]

J Nanobiotechnology
Zhang S, Li M, Li Y, Yang S, Wang J, Ren X, Wang X, Bai L, Huang J, Geng Z, Han G, Fang Y, Su J.   +12 more
europepmc   +1 more source

Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex

Advanced Science, EarlyView.
Ingenious introduction of an imine bond into an Ir(III)‐ferrocene complex effectively disrupts the photoinduced electron transfer process. Allowing full use of the TME to boost the efficacy of PDT, the molecule releases the Ir(III) complex and ferrocene with synergistic enhanced therapeutic effects of PDT and ferroptosis.
Yu Pei, Yinzhen Pan, Zhijun Zhang, Jun Zhu, Yan Sun, Qian Zhang, Dongxia Zhu, Guangzhe Li, Martin R. Bryce, Dong Wang, Ben Zhong Tang   +10 more
wiley   +1 more source

Transplantation of gastric epithelial mitochondria into human gastric cancer cells inhibits tumor growth and enhances chemosensitivity by reducing cancer stemness and modulating gastric cancer metabolism. [PDF]

Stem Cell Res Ther
Tsai HY, Tsai KJ, Wu DC, Huang YB, Lin MW.   +4 more
europepmc   +1 more source

Targeting mitochondria metabolism for cancer therapy.

Nature Chemical Biology, 2015
S. Weinberg, N. Chandel
semanticscholar   +1 more source