Results 351 to 360 of about 1,007,169 (424)

Isolation of Intact Mitochondria From Drosophila melanogaster and Assessment of Mitochondrial Respiratory Capacity Using Seahorse Analyzer. [PDF]

Bio Protoc
Groen CM, Windebank AJ.
europepmc   +1 more source

Dual‐Gating Strategy: Ultrasound Activation of TRPV2 Channels and Borate‐Glass‐Induced Calcium Overload for Tumor Suppression

Advanced Science, EarlyView.
A novel strategy combining borate glass and ultrasound is proposed for the precise treatment of breast cancer. The locally delivered borate glass releases Ca2⁺ ions in situ, while ultrasound activates the highly expressed transient receptor potential vanilloid 2 channels in breast cancer cells. This synergistic effect induces specific calcium overload,
Haihong Zhu, Liping Ouyang, Yangguang Huang, Ji Tan, Chunyu Liu, Qian Wang, Rongkun Huang, Wing Tak Wong, Xuanyong Liu, Haobo Pan, Yun Liao   +10 more
wiley   +1 more source

Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice. [PDF]

Sci Rep
Keller N, Christensen TA, Wanberg EJ, Salisbury JL, Trushina E.   +4 more
europepmc   +1 more source

Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia‐Induced Vascular Injury

Advanced Science, EarlyView.
Mitophagy switching drives high‐glucose‐induced vascular endothelial injury. Short‐term high‐glucose exposure upregulates Fis1 expression and enhances Fis1‐TBC1D15 interaction, activating Parkin‐mediated mitophagy. Long‐term high‐glucose exposure reduces Fis1 expression, inhibiting Parkin‐mediated mitophagy and triggering mitophagy switching from ...
Anqi Luo, Rui Wang, Jingwen Gong, Shuting Wang, Chuan Yun, Zongcun Chen, Yanan Jiang, Xiaoquan Liu, Haofu Dai, Haochen Liu, Yunsi Zheng   +10 more
wiley   +1 more source

Protective Effects of Adipose Mesenchymal Stem Cell Secretome On Oxidative Stress-Induced Bisphenol-A in Isolated Rat Testes Mitochondria and Sperm Quality. [PDF]

JBRA Assist Reprod
Soleimani MZ, Khorsandi L, Asadi-Fard Y, Rezaei-Tazangi F, Ashtari A.   +4 more
europepmc   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

Advanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou   +9 more
wiley   +1 more source

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

Advanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu   +12 more
wiley   +1 more source

Are Mitochondria a Potential Target for Treating β-Thalassemia? [PDF]

J Clin Med
Di Pierro E, Di Stefano V, Migone De Amicis M, Graziadei G.   +3 more
europepmc   +1 more source

Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, EarlyView.
The single‐atom doped molybdenum disulfide piezocatalyst markedly enhances both piezoelectric and enzyme‐mimicking activities, accelerating glutathione depletion. It induces mitochondrial dysfunction and cell cycle arrest, ultimately driving apoptosis while inactivating glutathione peroxidase 4 to initiate ferroptosis.
Haomiao Bai, Sujun Ding, Yanfei Dai, Jiefu Liu, Huangjing Chen, Wei Feng, Dehong Yu, Yu Chen, Xuejun Ni   +8 more
wiley   +1 more source

The Essential Role of Mitochondrial Dynamics in Viral Infections. [PDF]

Int J Mol Sci
Duan X, Liu R, Lan W, Liu S.
europepmc   +1 more source