Results 121 to 130 of about 9,815,793 (361)

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Primary mitochondrial disease in the US: Data from patients and physicians' perspective on health care delivery

Data in Brief, 2019
This article presents data that examine the patient's perception of health care delivery for mitochondrial disease in the US. It also presents the opinions of mitochondrial disease expert physicians about creating a specialised network of clinics to ...
Amel Karaa, Amy Goldstein, Cristy Balcells, Kira Mann, Laura Stanley, Philip E. Yeske, Sumit Parikh   +6 more
doaj  

"Mitochondrial myopathy" or mitochondrial disease? EEG, ERG, VEP studies in 13 children. [PDF]

, 1982
A. Harden, G. Pampiglione, Agatino Battaglia   +2 more
openalex   +1 more source

Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease

Bioscience Reports, 2016
Mitochondria provide the main source of energy to eukaryotic cells, oxidizing fats and sugars to generate ATP. Mitochondrial fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are two metabolic pathways which are central to this process.
Abena Nsiah-Sefaa, M. McKenzie
semanticscholar   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Renal manifestations of genetic mitochondrial disease

International Journal of Nephrology and Renovascular Disease, 2014
John F O'Toole Department of Internal Medicine, Division of Nephrology, MetroHealth Medical System, Case Western Reserve University School of Medicine, Cleveland, OH, USA Abstract: Mitochondrial diseases can be related to mutations in either the ...
O’Toole JF
doaj  

Monitoring clinical progression with mitochondrial disease biomarkers

Brain : a journal of neurology, 2017
The absence of well-characterised biomarkers for mitochondrial disease is restricting the development of new treatments. Steele et al. review current and future clinical biomarkers, discuss their relative strengths and weaknesses, and suggest ways ...
H. Steele, R. Horvath, Jon Lyon, P. Chinnery   +3 more
semanticscholar   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

AIFM1 mutation presenting with fatal encephalomyopathy and mitochondrial disease in an infant

Cold Spring Harbor molecular case studies, 2017
Apoptosis-inducing factor mitochondrion-associated 1 (AIFM1), encoded by the gene AIFM1, has roles in electron transport, apoptosis, ferredoxin metabolism, reactive oxygen species generation, and immune system regulation.
S. Morton, S. Prabhu, H. Lidov, Jiahai Shi, I. Anselm, C. Brownstein, M. Bainbridge, A. Beggs, S. Vargas, P. Agrawal   +9 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source