Results 211 to 220 of about 472,601 (312)

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

, 2002
Todd Sherer, Ranjita Betarbet, Amy K. Stout, Serena Lund, Melisa J. Baptista, Alexander Panov, Mark Cookson, J. Timothy Greenamyre   +7 more
openalex   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease. [PDF]

Commun Biol
Faitg J, Davey T, Laws R, Lawless C, Tuppen H, Fitton E, Turnbull D, Vincent AE.   +7 more
europepmc   +1 more source

Genetic diseases of the mitochondrial DNA [PDF]

, 2001
Abelardo Solano, Ana Playán, Manuel J. López‐Pérez, Julio Montoya   +3 more
openalex  

The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease

, 2002
Leo Nijtmans, Marta Artal‐Sanz, Les Grivell, Philip J. Coates   +3 more
openalex   +2 more sources

Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim, Woochan Kim, Harshita Sharma, Shinyull Lee, Chaeyeon Park, Sunho Park, Chan Yeong Heo, Jangho Kim   +7 more
wiley   +1 more source

Balancing Anesthesia in a Child With Mitochondrial Disease: A Case Report. [PDF]

Cureus
Manickam A, Fathima K, Bagri VA, Ganesh Prabu AVP, R VP.   +4 more
europepmc   +1 more source

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, EarlyView.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Correction: Comprehensive review of mitochondrial nephropathy-a renal phenotype in mitochondrial disease: causative genes, clinical and pathological features, diagnosis, prognosis, and treatment. [PDF]

Clin Exp Nephrol
Imasawa T, Murayama K, Hirano D, Nozu K.
europepmc   +1 more source

3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration

Advanced Healthcare Materials, EarlyView.
A kidney‐specific bioink derived from decellularized porcine kidney tissue supports the encapsulation, viability, and maturation of human primary kidney cells within 3D bioprinted constructs. In vivo, it also promotes the recruitment of host renal progenitor cells, collectively enhancing structural and functional regeneration of renal tissue.
Gabriel Carreno‐Galeano, Mohamed Ali, James J. Yoo, Sang Jin Lee, Anthony Atala   +4 more
wiley   +1 more source