Results 191 to 200 of about 615,187 (312)

Clinical Heterogeneity and Candidate Biomarkers in <i>POLG</i>-Related Mitochondrial Disease. [PDF]

Neurol Genet
Bermejo-Guerrero L, Restrepo-Vera JL, Martin-Jimenez P, Navarro-Riquelme M, Garrido-Moraga R, Ochoa LE, González-Quintana A, Hernandez-Lain A, Castillo-Villalba J, Morís G, Muelas N, García-Arumí E, González V, Martínez-Sáez E, Vesperinas A, Llansó L, Juntas-Morales R, Paradas C, Kapetanovic S, Blázquez A, Martí R, Arenas J, Martín MA, Domínguez-González C.   +23 more
europepmc   +1 more source

Molecular Genetics of Dupuytren´s Disease

, 2012
Dupuytren’s disease (DD) is a fibromatosis of connective tissue within the palm of the hands. It is characterised by progressive collagen deposition that leads to hardening and thickening of the connective tissue and results in permanent contraction of ...
Becker, Kerstin
core  

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Fontaine progeroid syndrome with neonatal mitochondrial disease. [PDF]

Hum Genome Var
Riko M, Kawamoto D, Hirayama K, Tsuchihashi T, Suzuki T, Sugimoto T, Okazaki Y, Murayama K, Tokuhara D.   +8 more
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

A step from the physiology to the physiome

Integrative Medicine Research, 2016
Akinori Noma, Jae Boum Youm
doaj   +1 more source

Molecular pathogenesis and gene therapy-based intervention of GTPBP3-related mitochondrial disease. [PDF]

Nat Commun
Zhang Y, Yao SY, Li J, Yu T, Liu H, Zhu N, Peng GX, Zheng WQ, Ma CR, Wang ED, Song C, Zhou XL.   +11 more
europepmc   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Neurological manifestations and genotype-phenotype correlations in <i>NDUFAF6</i>-associated mitochondrial disease. [PDF]

Brain Commun
Torraco A, Alston CL, Barcia G, Verrigni D, Rizza T, Di Nottia M, Altobelli A, Martinelli D, Diodato D, Efthymiou S, Kose M, Kriouile Y, Lim AZ, Morlino S, Siri B, Saadi NW, Novelli A, Houlden H, Dionisi-Vici C, McFarland R, Rötig A, Bertini E, Taylor RW, Carrozzo R.   +23 more
europepmc   +1 more source