Results 261 to 270 of about 533,276 (294)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α. [PDF]

J Clin Invest
Wang H, Miranda M, Marutani E, Lichtenegger P, Wojtkiewicz GR, Ichinose F, Mootha VK.   +6 more
europepmc   +1 more source

Mitochondrial disease in children : from clinical presentation to genetic background

, 2016
K Naess
openalex  

Unilateral Hearing Loss and Auditory Asymmetry in Mitochondrial Disease: A Scoping Review. [PDF]

J Clin Med
Manuelli M, Migliorelli A, Bianchini C, Stomeo F, Pelucchi S, Genovese E, Monzani D, Palma S, Ciorba A.   +8 more
europepmc   +1 more source

Prenatal and progressive coenzyme Q₁₀ administration to mitigate muscle dysfunction in mitochondrial disease. [PDF]

J Cachexia Sarcopenia Muscle
Hernández-Camacho JD, Vicente-García C, Ardila-García L, Padilla-Campos A, López-Lluch G, Santos-Ocaña C, Zammit PS, Carvajal JJ, Navas P, Fernández-Ayala DJM.   +9 more
europepmc   +1 more source

Optimizing rare disorder trials: a phase 1a/1b randomized study of KL1333 in adults with mitochondrial disease. [PDF]

Brain
Pizzamiglio C, Stefanetti RJ, McFarland R, Thomas N, Ransley G, Hugerth M, Grönberg A, Serrano SS, Elmér E, Hanna MG, Hansson MJ, Gorman GS, Pitceathly RDS.   +12 more
europepmc   +1 more source

Measurement of Twitch Dynamics in Response to Exercise Induced Changes in Mitochondrial Disease Using Motor Unit Magnetic Resonance Imaging (MUMRI): A Proof-of-Concept Study. [PDF]

NMR Biomed
Birkbeck MG, Elameer M, Heskamp L, Newman J, Stefanetti RJ, Barrow I, Pogoryelova O, Gorman GS, Hall J, Schofield IS, Blamire AM, Whittaker RG.   +11 more
europepmc   +1 more source

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Mitochondrial diseases

Neurologic Clinics, 2002
Since the first reports of disorders associated with mitochondrial DNA (mtDNA) defects more than a decade ago, the small mtDNA circle has been a Pandora's box of pathogenic mutations associated with human diseases. The "morbidity map" of mtDNA has gone from one point mutation and a few deletions in 1988 to more than 110 point mutations as of September,
Tuan H, Vu, Michio, Hirano, Salvatore, DiMauro   +2 more
openaire   +4 more sources