Results 241 to 250 of about 899,069 (291)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Severe clinical manifestation of mitochondrial disease due to the m.3243A>T variant: a case report of early-onset, multi-organ involvement and premature death. [PDF]

J Rare Dis (Berlin)
Gillespie H, Ng YS, Wood KM, Hopton S, Alston CL, Blakely EL, Thompson N, Taylor RW, Browning AC, McFarland R, Sayer JA.   +10 more
europepmc   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease. [PDF]

Commun Biol
Faitg J, Davey T, Laws R, Lawless C, Tuppen H, Fitton E, Turnbull D, Vincent AE.   +7 more
europepmc   +1 more source

COVID-19 Infection as a Possible Trigger for POLG-Related Mitochondrial Disease: A Case Report. [PDF]

Cureus
Suroviaková S, Zolak V, Igaz M, Kršiaková J, Bánovčin P.   +4 more
europepmc   +1 more source

Imaging flow cytometry reveals divergent mitochondrial phenotypes in mitochondrial disease patients. [PDF]

iScience
Muffels IJJ, Rodenburg R, Willemen HLD, van Haaften-Visser D, Waterham H, Eijkelkamp N, Fuchs SA, van Hasselt PM.   +7 more
europepmc   +1 more source

Uncommon case of mitochondrial disease: Mild amyotrophy of the legs and symmetrical lipomatosis of the arms. [PDF]

J Inherit Metab Dis
Bercu L, Amati-Bonneau P, Desquiret-Dumas V, Procaccio V, Maillot F.   +4 more
europepmc   +1 more source

Correction: Comprehensive review of mitochondrial nephropathy-a renal phenotype in mitochondrial disease: causative genes, clinical and pathological features, diagnosis, prognosis, and treatment. [PDF]

Clin Exp Nephrol
Imasawa T, Murayama K, Hirano D, Nozu K.
europepmc   +1 more source

Clinical features and treatment of stroke-like episodes in mitochondrial disease: a cohort-based study. [PDF]

J Neurol
Mickelsson N, Hirvonen J, Martikainen MH.   +2 more
europepmc   +1 more source

ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation.

Cell Rep
Bordi M, Testa B, Compagnucci C, Colasuonno F, Cipressa F, Betterini E, Mancini A, Carsetti C, Salvatori I, Ferraina C, Yang M, De Cegli R, Del Prete E, Veroni C, Rizza S, Mauri S, Ziviani E, Macchiaiolo M, Vecchio D, Panfili FM, Rizza T, Weber G, Carrozzo R, Ferri A, Campello S, Ballabio A, Frezza C, Cestra G, Tartaglia M, Bartuli A, Cecconi F.   +30 more
europepmc   +1 more source