Results 261 to 270 of about 615,187 (312)

LNC-ing Genetics in Mitochondrial Disease. [PDF]

Noncoding RNA
Kamps R, Robinson EL.
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity. [PDF]

Mol Genet Metab
Huang Q, Trumpff C, Monzel AS, Rausser S, Devine J, Liu CC, Kelly C, Kurade M, Li S, Engelstad K, Tanji K, Lauriola V, Wang T, Wang S, Sloan R, Juster RP, Hirano M, Picard M.   +17 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Polyamine metabolism is dysregulated in COXFA4-related mitochondrial disease. [PDF]

HGG Adv
Marquez J, Viviano S, Beckman E, Thies J, Friedland-Little J, Lam CT, Deniz E, Shelkowitz E.   +7 more
europepmc   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Management of anesthesia in a child with mitochondrial disease for dental rehabilitation. [PDF]

J Anaesthesiol Clin Pharmacol
Bhuyan M, Rajan S, Atri P, Paul J.
europepmc   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Hepatic bioenergetics and metabolism in mitochondrial disease: insights from the Ndufs4 KO mouse model. [PDF]

Metabolomics
Terburgh K, Sweeney N, Louw R.
europepmc   +1 more source

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease. [PDF]

Nat Commun
VanPortfliet JJ, Lei Y, Ramanathan M, Martinez CG, Wong J, Stodola TJ, Hoffmann BR, Pflug K, Sitcheran R, Kneeland SC, Murray SA, McGuire PJ, Cannon CL, West AP.   +13 more
europepmc   +1 more source