Results 101 to 110 of about 10,033,806 (381)

GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction

PLoS ONE, 2016
Background We previously described increased levels of growth and differentiation factor 15 (GDF-15) in skeletal muscle and serum of patients with mitochondrial diseases.
R. Montero, D. Yubero, J. Villarroya, D. Henares, C. Jou, M. A. Rodríguez, F. Ramos, A. Nascimento, C. Ortez, J. Campistol, B. Pérez-Dueñas, M. O’Callaghan, M. Pineda, Á. García-Cazorla, J. C. Oferil, J. Montoya, E. Ruiz‐Pesini, S. Emperador, M. Meznaric, Laura Campderrós, S. Kalko, F. Villarroya, R. Artuch, C. Jiménez-Mallebrera   +23 more
semanticscholar   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy

Arthritis Research & Therapy
Objective Limb-girdle muscular dystrophy (LGMD) is usually confused with idiopathic inflammatory myopathy (IIM) in clinical practice. Our study aimed to establish convenient and reliable diagnostic models for distinguishing between LGMD and IIM.
Guangyu Wang, Lijun Fu, Lining Zhang, Kai Shao, Ying Hou, Tingjun Dai, Pengfei Lin, Chuanzhu Yan, Bing Zhao   +8 more
doaj   +1 more source

Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability

EMBO Molecular Medicine, 2023
Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria, with the two isoforms playing specialised roles in DNA recombination and replication ...
Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A de Moura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls   +32 more
doaj   +1 more source

Apricot melanoidins prevent oxidative endothelial cell death by counteracting mitochondrial oxidation and membrane depolarization [PDF]

, 2012
The cardiovascular benefits associated with diets rich in fruit and vegetables are thought to be due to phytochemicals contained in fresh plant material.
Capobianco, Giampiero, Cossu, Annalisa, Emanueli, Costanza, Giordo, Roberta, Piga, Antonio <1965- >, Pintus, Gianfranco, Piscopo, Amalia, Poiana, Marco, Posadino, Anna Maria, Sanguinetti, Anna Maria   +9 more
core   +2 more sources

Mitochondrial disease in children [PDF]

Journal of Internal Medicine, 2020
AbstractMitochondrial disease presenting in childhood is characterized by clinical, biochemical and genetic complexity. Some children are affected by canonical syndromes, but the majority have nonclassical multisystemic disease presentations involving virtually any organ in the body.
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass

Scientific Reports, 2021
O-GlcNAcylation is a prevalent form of glycosylation that regulates proteins within the cytosol, nucleus, and mitochondria. The O-GlcNAc modification can affect protein cellular localization, function, and signaling interactions. The specific impact of O-
Elizabeth O. Akinbiyi, Lara K. Abramowitz, Brianna L. Bauer, Maria S. K. Stoll, Charles L. Hoppel, Chao-Pin Hsiao, John A. Hanover, Jason A. Mears   +7 more
doaj   +1 more source

Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis [PDF]

, 2011
Oxidative stress is one of the factors that could explain the pathophysiological mechanism of inflammatory conditions that occur in cardiovascular disease (CVD) and periodontitis.
Battino, Maurizio, Bullon, Pedro, Cordero Morales, Mario David, Morillo, J.M., Quiles, José L., Ramirez Tortosa, Maria Carmen   +5 more
core  

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA [PDF]

, 2014
The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of heteroplasmy (the presence of several alleles in an individual), yet its transmission across generations cannot be readily predicted owing to a lack of data on the size ...
A. Nekrutenko, Abu-Amero, Ashley, B. Dickins, B. Rebolledo-Jaramillo, Barritt, Barritt, Bartmann, Cao, Chinnery, D. Blankenberg, del Castillo, Denver, Du, Eichenlaub-Ritter, F. Chiaromonte, Galtier, Goto, Guo, Haag-Liautard, Helgadottir, Hindson, Howell, Howell, I. M. Paul, J. A. McElhoe, Jenuth, K. D. Makova, Kong, Larsson, Li, Li, Lutz, Lynch, M. M. Holland, M. S.-W. Su, Ma, Marchington, Millar, Monnot, N. Stoler, Olivo, Parsons, Prasad, R. Nielsen, Rollins, Seifer, Shu, Sigur  ard  ttir, Simone, T. S. Korneliussen, Tang, Wai, Wallace, Wortmann   +54 more
core   +2 more sources