Results 301 to 310 of about 10,050,443 (381)

MITOCHONDRIAL DNA MUTATIONS CAUSE DISEASE, APOPTOSIS, AND PERMEABILITY TRANSITION PORE DYSFUNCTION

, 2001
Justin L. Mott, Dekui Zhang, Hans Peter Zassenhaus   +2 more
openalex   +1 more source

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease [PDF]

, 2003
Joelle M. van der Walt, Kristin K. Nicodemus, Eden R. Martin, William K. Scott, Martha Nance, Ray L. Watts, Jean Hubble, Jonathan L. Haines, William C. Koller, Kelly E. Lyons, Rajesh Pahwa, Matthew B. Stern, Amy Colcher, Bradley C. Hiner, Joseph Jankovic, William G. Ondo, Fred H. Allen, Christopher G. Goetz, Gary W. Small, Frank Mastaglia, Jeffrey M. Stajich, Adam C. McLaurin, Lefkos Middleton, B.L. Scott, Donald E. Schmechel, Margaret A. Pericak‐Vance, Jeffery M. Vance   +26 more
openalex   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Current global vitamin and cofactor prescribing practices for primary mitochondrial diseases: Results of a European reference network survey. [PDF]

J Inherit Metab Dis
Neugebauer J, Reinson K, Bellusci M, Park JH, Hikmat O, Bertini E, Schiff M, MetabERN PM‐MD Consortium authors, Rahman S.   +8 more
europepmc   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Endocrine features of primary mitochondrial diseases. [PDF]

Curr Opin Endocrinol Diabetes Obes
Romo L, Gold NB, Walker MA.
europepmc   +1 more source

AnIn VitroModel of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

, 2002
Todd Sherer, Ranjita Betarbet, Amy K. Stout, Serena Lund, Melisa J. Baptista, Alexander Panov, Mark Cookson, J. Timothy Greenamyre   +7 more
openalex   +1 more source

Ketogenic diets: from cancer to mitochondrial diseases and beyond

European Journal of Clinical Investigation, 2016
A. Branco, André Ferreira, Rui F. Simões, Sílvia Magalhães‐Novais, Cheryl Zehowski, Elisabeth Cope, A. M. Silva, D. Pereira, V. Sardão, Teresa Cunha-Oliveira   +9 more
semanticscholar   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

The establishment of a molecular diagnostic platform for mitochondrial diseases: From conventional to next-generation sequencing. [PDF]

Biomed J
Tsai NC, Liou CW, Cheng YH, Lien HT, Lin TL, Lin TK, Lan MY, Hung PL, Wang TJ, Lee CH, Liang YC, Lan KC.   +11 more
europepmc   +1 more source