Results 281 to 290 of about 2,946,422 (305)

MITOCHONDRIAL INHERITANCE AND DISEASE

The Lancet, 1978
Spontaneously occurring variants of the D.N.A. content of mitochondria may be responsible for human disease. Among the prime candidates for such a mitochondrial aetiology are certain drug-induced blood dyscrasias, particularly that due to chloramphenicol.
openaire   +2 more sources

A history of mitochondrial diseases

Journal of Inherited Metabolic Disease, 2010
AbstractThis articles reviews the development of mitochondrial medicine from the premolecular era (1962–1988), when mitochondrial diseases were defined on the basis of clinical examination, muscle biopsy, and biochemical criteria, through the molecular era, when the full complexity of these disorders became evident.
openaire   +2 more sources

Mitochondrial Dynamics in Disease

New England Journal of Medicine, 2007
Mitochondria are subcellular organelles that coordinate numerous metabolic reactions, including those of the respiratory complexes that produce the ATP that powers cellular reactions. They have often been depicted as static, with a kidney-bean shape, but there is a growing appreciation of their dynamic nature.
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Primary mitochondrial diseases

Primary mitochondrial diseases (PMDs) are a heterogeneous group of hereditary disorders characterized by an impairment of the mitochondrial respiratory chain. They are the most common group of genetic metabolic disorders, with a prevalence of 1 in 4,300 people.
Chiara, Pizzamiglio, Michael G, Hanna, Robert D S, Pitceathly   +2 more
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Genetics of Mitochondrial Disease

2017
Mitochondria are intracellular organelles responsible for adenosine triphosphate production. The strict control of intracellular energy needs require proper mitochondrial functioning. The mitochondria are under dual controls of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA).
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Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

Acta Pharmacologica Sinica, 2022
Zheng-Hong Qin
exaly  

Mitochondrial Unfolded Protein Response and Integrated Stress Response as Promising Therapeutic Targets for Mitochondrial Diseases

Cells, 2023
Ya-jing Liu, Chunmei Liang, Weiwei Zou
exaly  

Mitochondrial Iron Metabolism: The Crucial Actors in Diseases

Molecules, 2023
Fengna Li, Yehui Duan
exaly  

mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases

International Journal of Molecular Sciences, 2023
José A Sánchez-Alcázar, Alejandra Suárez Carrillo, David Gómez-Fernandez   +2 more
exaly  

Mitochondrial DNA and disease

The Lancet, 1999
P F, Chinnery, D M, Turnbull
openaire   +2 more sources