Results 1 to 10 of about 56,530 (315)

Coordinating mitochondrial translation with assembly of the OXPHOS complexes [PDF]

Human Molecular Genetics
The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are encoded
Peter Rehling, Rehling Peter
exaly   +8 more sources

Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers [PDF]

International Journal of Molecular Sciences, 2021
Increasing evidence suggests that tumor development requires not only oncogene/tumor suppressor mutations to drive the growth, survival, and metastasis but also metabolic adaptations to meet the increasing energy demand for rapid cellular expansion and ...
Ching-Yu Lin, Ching Yu Lin, Chia-Lin Chen   +2 more
exaly   +5 more sources

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer [PDF]

Cell Reports Medicine, 2020
Summary Mitochondrial respiration (oxidative phosphorylation, OXPHOS) is an emerging target in currently refractory cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the variability of energetic metabolic adaptations between PDAC patients
Alice Carrier, Tristan Gicquel, Nelson Dusetti   +2 more
exaly   +3 more sources

OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer [PDF]

Redox Biology
The hypothesis of a significant shift from oxidative phosphorylation (OXPHOS) to glycolysis in a number of solid tumors has been dominant for many years.
Cemile Uslu, Eda Kapan, Alex Lyakhovich
doaj   +3 more sources

OXPHOS-targeting drugs in oncology: New perspectives [PDF]

Expert Opinion on Therapeutic Targets, 2023
Introduction Drugs targeting mitochondria are emerging as promising antitumor therapeutics in preclinical models. However, a few of these drugs have shown clinical toxicity.
B. Kalyanaraman, Gang Cheng, M. Hardy, Ming You   +3 more
semanticscholar   +5 more sources

Secondary coenzyme Q 10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders [PDF]

Mitochondrion, 2016
We evaluated the coenzyme Q₁₀ (CoQ) levels in patients who were diagnosed with mitochondrial oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders (n=72). Data from the 72 cases in this study revealed that 44.4% of patients showed low CoQ concentrations in either their skeletal muscle or skin fibroblasts.
Yubero, D., Montero, R., Martín, M. A., Montoya, J., Ribes, A., Grazina, M., Trevisson, E., Rodriguez-Aguilera, J., Hargreaves, I. P., Salviati, L., Navas, P., Artuch, R., Jou, C., Jimenez-Mallebrera, C., Nascimento, A., Pérez-Dueñas, B., Ortez, C., Ramos, F., Colomer, J., O''Callaghan, M., Pineda, M., García-Cazorla, A., Espinós, C., Ruiz, A., Macaya, A., Marcé-Grau, A., Garcia-Villoria, J., Arias, A., Emperador, S., Ruiz-Pesini, E., Lopez-Gallardo, E., Neergheen, V., Simões, M., Diogo, L., Blázquez, A., González-Quintana, A., Delmiro, A., Domínguez-González, C., Arenas, J., García-Silva, M. T., Martín, E., Quijada, P., Hernández-Laín, A., Morán, M., Rivas Infante, E., Ávila Polo, R., Paradas Lópe, C., Bautista Lorite, J., Martínez Fernández, E. M., Cortés, A. B., Sánchez-Cuesta, A., Cascajo, M. V., Alcázar, M., Brea-Calvo, G.   +53 more
core   +10 more sources

OXPHOS mutations and neurodegeneration [PDF]

The EMBO Journal, 2012
Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit complexes (CI-CV) that are built up of 92 different structural proteins encoded by the nuclear (nDNA) and mitochondrial DNA (mtDNA).
Koopman, W.J.H., Distelmaier, F., Smeitink, J.A.M., Willems, P.H.G.M.   +3 more
openaire   +6 more sources

OXPHOS toxicogenomics and Parkinson's disease [PDF]

Mutation Research/Reviews in Mutation Research, 2011
Activities and quantities of several oxidative phosphorylation (OXPHOS) system complexes are decreased in many Parkinson's disease (PD) patients. Mutations in PD-associated nuclear genes affect OXPHOS function. Moreover, the inactivation of other nuclear genes related to mitochondrial DNA (mtDNA) replication and expression also leads to Parkinsonism ...
López-Gallardo,E., Iceta,R., Iglesias,E., Montoya,J., Ruiz-Pesini,E.   +4 more
openaire   +4 more sources

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

Scientific Reports, 2023
Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability to discriminate between non-cancerous and cancerous mitochondria.
Ilya N. Boykov, McLane M. Montgomery, James T. Hagen, Raphael T. Aruleba, Kelsey L. McLaughlin, Hannah S. Coalson, Margaret A. Nelson, Andrea S. Pereyra, Jessica M. Ellis, Tonya N. Zeczycki, Nasreen A. Vohra, Su-Fern Tan, Myles C. Cabot, Kelsey H. Fisher-Wellman   +13 more
doaj   +2 more sources

Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases [PDF]

Journal of Cell Biology, 2017
Mitochondria participate in essential processes in the nervous system such as energy and intermediate metabolism, calcium homeostasis, and apoptosis. Major neurodegenerative diseases are characterized pathologically by accumulation of misfolded proteins as a result of gene mutations or abnormal protein homeostasis.
Hibiki Kawamata, Giovanni Manfredi
openaire   +4 more sources