Results 21 to 30 of about 51,036 (282)
Redox Biology, 2019 The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime ...
Li Ren Kong +2 more
exaly +3 more sources
OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer
Redox BiologyThe hypothesis of a significant shift from oxidative phosphorylation (OXPHOS) to glycolysis in a number of solid tumors has been dominant for many years.
Cemile Uslu, Eda Kapan, Alex Lyakhovich
doaj +2 more sources
Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction [PDF]
Cells, 2020 Mitochondrial oxidative phosphorylation (OXPHOS) defects are the primary cause of inborn errors of energy metabolism. Despite considerable progress on their genetic basis, their global pathophysiological consequences remain undefined.
Alberto García-Bartolomé +10 more
doaj +2 more sources
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid-derived suppressor cells. [PDF]
FEBS Open BioBCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Chen Y, Li H.
europepmc +2 more sources
HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS
Advanced ScienceOxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) are key bioenergetics pathways. The machineries for both processes are localized in mitochondria.
Chaoying Qin +15 more
doaj +2 more sources
Regulation of Metabolism by Hepatic OXPHOS: A Dissertation
, 2015 Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent issue in the modern world, predisposing patients to serious pathology such as cirrhosis and hepatocellular carcinoma. Mitochondrial dysfunction, and in particular, diminished hepatic oxidative phosphorylation (OXPHOS) capacity, have been observed in NAFLD livers, which may ...
Akie, Thomas E.
openaire +3 more sources
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription. [PDF]
FEBS Open BioIn this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Wang L +10 more
europepmc +2 more sources
Frontiers in Immunology, 2022 As the major hub of metabolic activity and an organelle sequestering pro-apoptogenic intermediates, mitochondria lie at the crossroads of cellular decisions of death and survival.
Neetu Saini +4 more
doaj +1 more source
Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer
Cells, 2020 Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was
Anderson Vulczak +5 more
doaj +1 more source
TEAD4 as an Oncogene and a Mitochondrial Modulator
Frontiers in Cell and Developmental Biology, 2022 TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and ...
Sheng-Chieh Hsu +10 more
doaj +1 more source