Results 21 to 30 of about 46,956 (278)
Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. [PDF]
PLoS Genetics, 2013 Impaired mitochondrial oxidative phosphorylation (OXPHOS) has been proposed as an etiological mechanism underlying insulin resistance. However, the initiating organ of OXPHOS dysfunction during the development of systemic insulin resistance has yet to be
Min Jeong Ryu +20 more
doaj +4 more sources
Targeting OXPHOS and the electron transport chain in cancer; Molecular and therapeutic implications
Seminars in Cancer Biology, 2022 Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation ...
John Greene +2 more
exaly +3 more sources
Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
Cell Reports Medicine, 2020 International audienceHighlights d Pancreatic ductal adenocarcinoma (PDAC) displays OXPHOS heterogeneity d High OXPHOS PDAC tumors are enriched in mitochondrial respiratory complex I d Complex I inhibitor phenformin synergizes with chemotherapy in high ...
Gabriela Reyes-Castellanos +2 more
exaly +2 more sources
Bayesian classification of OXPHOS deficient skeletal myofibres [PDF]
PLOS Computational BiologyMitochondria are organelles in most human cells which release the energy required for cells to function. Oxidative phosphorylation (OXPHOS) is a key biochemical process within mitochondria required for energy production and requires a range of proteins ...
Golightly, Andrew
core +6 more sources
Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases [PDF]
Journal of Cell Biology, 2017 Mitochondria participate in essential processes in the nervous system such as energy and intermediate metabolism, calcium homeostasis, and apoptosis. Major neurodegenerative diseases are characterized pathologically by accumulation of misfolded proteins ...
Giovanni Manfredi, Hibiki Kawamata
core +3 more sources
Mitoribosomal regulation of OXPHOS biogenesis in plants [PDF]
Frontiers in Plant Science, 2014 The ribosome filter hypothesis posits that ribosomes are not simple non-selective translation machines but may also function as regulatory elements in protein synthesis. Recent data supporting ribosomal filtering come from plant mitochondria where it has
Malgorzata eKwasniak +3 more
core +4 more sources
Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation Disruption [PDF]
PharmaceuticalsBackground/Objectives: Mitochondrial Oxidative Phosphorylation (OXPHOS) is a critical metabolic dependency in many cancers. Targeting OXPHOS through Leucine-Rich PPR Motif-Containing Protein (LRPPRC) degrader-mediated OXPHOS Complex Biogenesis Inhibition
Jing Chen +7 more
doaj +2 more sources
OXPHOS inhibition overcomes chemoresistance in triple negative breast cancer
Redox BiologyThe hypothesis of a significant shift from oxidative phosphorylation (OXPHOS) to glycolysis in a number of solid tumors has been dominant for many years.
Cemile Uslu, Eda Kapan, Alex Lyakhovich
doaj +2 more sources
Redox Biology, 2019 The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime ...
Jie Qing Eu +2 more
exaly +3 more sources
OXPHOS-targeting drugs in oncology: new perspectives
Expert Opinion on Therapeutic Targets, 2023 International audienceIntroductionDrugs targeting mitochondria are emerging as promising antitumor therapeutics in preclinical models. However, a few of these drugs have shown clinical toxicity. Developing mitochondria-targeted modified natural compounds
Hardy, Micael +7 more
core +4 more sources