Results 21 to 30 of about 56,530 (315)

The molecular evolutionary dynamics of oxidative phosphorylation (OXPHOS) genes in Hymenoptera [PDF]

BMC Evolutionary Biology, 2017
Background The primary energy-producing pathway in eukaryotic cells, the oxidative phosphorylation (OXPHOS) system, comprises proteins encoded by both mitochondrial and nuclear genes.
Yiyuan Li, Rui Zhang, Shanlin Liu, Alexander Donath, Ralph S. Peters, Jessica Ware, Bernhard Misof, Oliver Niehuis, Michael E. Pfrender, Xin Zhou   +9 more
doaj   +3 more sources

Mitonuclear Coevolution, but not Nuclear Compensation, Drives Evolution of OXPHOS Complexes in Bivalves

Molecular Biology and Evolution, 2021
In Metazoa, four out of five complexes involved in oxidative phosphorylation (OXPHOS) are formed by subunits encoded by both the mitochondrial (mtDNA) and nuclear (nuDNA) genomes, leading to the expectation of mitonuclear coevolution.
Mariangela Iannello, Federico Plazzi, Fabrizio Ghiselli   +2 more
exaly   +2 more sources

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes [PDF]

Genome Biology and Evolution, 2015
The five macromolecular complexes that jointly mediate oxidative phosphorylation (OXPHOS) in mitochondria consist of many more subunits than those of bacteria, yet, it remains unclear by which evolutionary mechanism(s) these novel subunits were recruited.
E. O. van der Sluis, H. Bauerschmitt, T. Becker, T. Mielke, J. Frauenfeld, O. Berninghausen, W. Neupert, J. M. Herrmann, R. Beckmann   +8 more
openaire   +8 more sources

Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction [PDF]

Cells, 2020
Mitochondrial oxidative phosphorylation (OXPHOS) defects are the primary cause of inborn errors of energy metabolism. Despite considerable progress on their genetic basis, their global pathophysiological consequences remain undefined.
Alberto García-Bartolomé, Ana Peñas, María Illescas, Verónica Bermejo, Sandra López-Calcerrada, Rafael Pérez-Pérez, Lorena Marín-Buera, Cristina Domínguez-González, Joaquín Arenas, Miguel A. Martín, Cristina Ugalde   +10 more
doaj   +3 more sources

Regulation of Metabolism by Hepatic OXPHOS: A Dissertation [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent issue in the modern world, predisposing patients to serious pathology such as cirrhosis and hepatocellular carcinoma. Mitochondrial dysfunction, and in particular, diminished hepatic oxidative phosphorylation (OXPHOS) capacity, have been observed in NAFLD livers, which may ...
Akie, Thomas E.
openaire   +3 more sources

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

Redox Biology, 2019
The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime ...
Li Ren Kong, Marie-Veronique Clement, Boon Cher Goh   +2 more
exaly   +3 more sources

Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation Disruption [PDF]

Pharmaceuticals
Background/Objectives: Mitochondrial Oxidative Phosphorylation (OXPHOS) is a critical metabolic dependency in many cancers. Targeting OXPHOS through Leucine-Rich PPR Motif-Containing Protein (LRPPRC) degrader-mediated OXPHOS Complex Biogenesis Inhibition
Jing Chen, Lu Gao, Yuxin Liang, Wei Zhou, Yong Wang, Xiaojia Wang, Xiaohong Fang, Xiying Shao   +7 more
doaj   +2 more sources

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS [PDF]

Advanced Science
Oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) are key bioenergetics pathways. The machineries for both processes are localized in mitochondria.
Chaoying Qin, Shasha Gong, Ting Liang, Zhenbo Zhang, Jessie Thomas, Janice Deng, Yaguang Liu, Peiqing Hu, Bi Zhu, Shujie Song, Marisol Fernández Ortiz, Yuji Ikeno, Exing Wang, James Lechleiter, Susan T. Weintraub, Yidong Bai   +15 more
doaj   +2 more sources

Lactylation constrains OXPHOS under hypoxia

Cell Research
Haowen Ren, Di Zhang
semanticscholar   +3 more sources

Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells

Frontiers in Immunology, 2022
As the major hub of metabolic activity and an organelle sequestering pro-apoptogenic intermediates, mitochondria lie at the crossroads of cellular decisions of death and survival.
Neetu Saini, Neetu Saini, Sowmya Lakshminarayanan, Priyanka Kundu, Apurva Sarin   +4 more
doaj   +1 more source