Mitoribosomal regulation of OXPHOS biogenesis in plants [PDF]
Frontiers in Plant Science, 2014 The ribosome filter hypothesis posits that ribosomes are not simple non-selective translation machines but may also function as regulatory elements in protein synthesis. Recent data supporting ribosomal filtering come from plant mitochondria where it has been shown that translation of mitochondrial transcripts encoding components of oxidative ...
Janska, Hanna, Kwasniak, Malgorzata
openaire +5 more sources
Targeting OXPHOS and the electronic transport chain in cancer; molecular and therapeutic implications. [PDF]
Seminars in Cancer Biology, 2022 Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation ...
J. Greene, A. Segaran, S. Lord
semanticscholar +3 more sources
Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways
International Journal of Molecular Sciences, 2020 The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which—given their dual-genetic control—requires tight co-regulation of two evolutionarily distinct gene expression machineries.
Monika Oláhová +2 more
exaly +2 more sources
OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment [PDF]
Science immunology, 2022 T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune ...
H. Hong +24 more
semanticscholar +3 more sources
Bayesian classification of OXPHOS deficient skeletal myofibres [PDF]
PLOS Computational BiologyMitochondria are organelles in most human cells which release the energy required for cells to function. Oxidative phosphorylation (OXPHOS) is a key biochemical process within mitochondria required for energy production and requires a range of proteins and protein complexes.
Jordan Childs +4 more
core +8 more sources
OXPHOS inhibitors, metabolism and targeted therapies in cancer.
Biochemical Pharmacology, 2023 More and more studies highlight the complex metabolic characteristics and plasticity of cancer cells. To address these specificities and explore the associated vulnerabilities, new metabolism-targeting therapeutic strategies are being developed.
Octavia Cadassou, Lars Petter Jordheim
semanticscholar +3 more sources
Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice. [PDF]
PLoS Genetics, 2013 Impaired mitochondrial oxidative phosphorylation (OXPHOS) has been proposed as an etiological mechanism underlying insulin resistance. However, the initiating organ of OXPHOS dysfunction during the development of systemic insulin resistance has yet to be
Min Jeong Ryu +20 more
doaj +6 more sources
Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction
Molecular Metabolism, 2022 Introduction Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system.
Pieter Vermeersch +2 more
exaly +2 more sources
Attenuates of NAD+ impair BMSC osteogenesis and fracture repair through OXPHOS
Stem Cell Research & Therapy, 2022 Background Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for bone regeneration and repair.
Boer Li +7 more
doaj +2 more sources
Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia [PDF]
eLife, 2021 Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non ...
Margaret A. M. Nelson +13 more
semanticscholar +2 more sources