Results 31 to 40 of about 51,036 (282)

Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics

Frontiers in Toxicology, 2022
Mitochondrial dysfunctions that were not discovered during preclinical and clinical testing have been responsible for at least restriction of use as far as withdrawal of many drugs.
Sylvain Loric, Marc Conti
doaj   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

In vitro assessment of stearyl triphenyl phosphonium toxicity in drug-resistant tumor cells

4 open, 2022
Introduction: The triphenyl phosphonium residue is a well-documented mitochondriotropic that has been shown to improve the accumulation of biomolecules in mitochondria. Stearyl triphenyl phosphonium (STPP) modified liposomes have been shown to facilitate
Shah Shrey, Ouellette Miller, D’Souza Gerard G. M.   +2 more
doaj   +1 more source

Mechanisms of venetoclax resistance and solutions

Frontiers in Oncology, 2022
The BCL-2 inhibitor venetoclax is currently approved for treatment of hematologic diseases and is widely used either as monotherapy or in combination strategies.
Jiachen Liu, Yidong Chen, Lihua Yu, Lihua Yang   +3 more
doaj   +1 more source

Mitochondrial complex II and reactive oxygen species in disease and therapy

Redox Report, 2020
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact ...
Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena   +3 more
doaj   +1 more source

ILF2 cooperates with E2F1 to maintain mitochondrial homeostasis and promote small cell lung cancer progression

Cancer Biology & Medicine, 2019
Objective Mitochondria play multifunctional roles in carcinogenesis. Deciphering uncertainties of molecular interactions within mitochondria will promote further understanding of cancer.
Meng Zhao, Yahui Liu, Jiao Chang, Jin Qi, Ran Liu, Yongwang Hou, Yanhui Wang, Xinwei Zhang, Lu Qiao, Li Ren   +9 more
doaj   +1 more source

Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

Cells, 2020
Cytochrome c oxidase (COX) is regulated through tissue-, development- or environment-controlled expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms ...
David Pajuelo Reguera, Kristýna Čunátová, Marek Vrbacký, Alena Pecinová, Josef Houštěk, Tomáš Mráček, Petr Pecina   +6 more
doaj   +1 more source

The regulation of OXPHOS by extramitochondrial calcium

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Despite extensive research, the regulation of mitochondrial function is still not understood completely. Ample evidence shows that cytosolic Ca2+ has a strategic task in co-ordinating the cellular work load and the regeneration of ATP by mitochondria. Currently, the paradigmatic view is that Cacyt2+ taken up by the Ca2+ uniporter activates the matrix ...
Gellerich, Frank N., Gizatullina, Zemfira, Trumbeckaite, Sonata, Nguyen, Huu P., Pallas, Thilo, Arandarcikaite, Odeta, Vielhaber, Stephan, Seppet, Enn, Striggow, Frank   +8 more
openaire   +2 more sources

Barcode plot of OXPHOS probes. [PDF]

, 2018
A plot demonstrating the ranks of each of the 1,344 OXPHOS probes with respect to all 420,132 included probes. Each black vertical line represents an OXPHOS probe. A centered cumulative sum is also plotted as a blue line.
Bove, Riley M., Schneider, Julie A., Julie A Schneider, Gyan Srivastava (5565842), Riley M Bove, Schneider, Julie A, Philip L. De Jager (202972), Aubin, Cristin McCabe, David A. Bennett (229710), Bennett, David A, De Jager, Philip Lawrence, De Jager, Philip L, Ellis Patrick, Gyan Srivastava, Chibnik, Lori B, David A Bennett, Ellis Patrick (4219258), Bennett, David A., Chibnik, Lori B., Bove, Riley M, Patrick, Ellis, Cristin McCabe Aubin, Julie A. Schneider (341811), Srivastava, Gyan, Lori B Chibnik, Riley M. Bove (482178), Cristin McCabe Aubin (5565839), Lori B. Chibnik (205940), Philip L De Jager   +28 more
core   +2 more sources

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions

Molecular & Cellular Oncology, 2021
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative ...
Eduardo Silva-Pavez, Ulises Ahumada-Castro, Alenka Lovy, Julio Cesar Cárdenas   +3 more
doaj   +1 more source