Results 31 to 40 of about 56,530 (315)

OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases

Communications Biology, 2023
Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic basis for this clinical picture remains unclear.
Gabriel Sturm, Kalpita R. Karan, Anna S. Monzel, Balaji Santhanam, T. Taivassalo, C. Bris, Sarah A. Ware, Marissa Cross, A. Towheed, A. Higgins-Chen, Meagan J. McManus, Andrés Cárdenas, Jue Lin, E. Epel, S. Rahman, J. Vissing, B. Grassi, M. Levine, S. Horvath, R. Haller, G. Lenaers, D. Wallace, M. St-Onge, Saeed Tavazoie, V. Procaccio, B. Kaufman, E. Seifert, M. Hirano, Martin Picard   +28 more
semanticscholar   +1 more source

Moderate Exercise Modulates Tumor Metabolism of Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) stands out for its aggressiveness and accelerated rate of proliferation. Evidence shows that exercise may exert antitumorigenic effects, but the biochemical mechanisms underlying them remain unclear. Our objective was
Anderson Vulczak, Anderson de Oliveira Souza, Gustavo Duarte Ferrari, Ana Elisa Caleiro Seixas Azzolini, Gabriela Pereira-da-Silva, Luciane Carla Alberici   +5 more
doaj   +1 more source

TEAD4 as an Oncogene and a Mitochondrial Modulator

Frontiers in Cell and Developmental Biology, 2022
TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and ...
Sheng-Chieh Hsu, Sheng-Chieh Hsu, Ching-Yu Lin, Yen-Yi Lin, Colin C. Collins, Chia-Lin Chen, Chia-Lin Chen, Hsing-Jien Kung, Hsing-Jien Kung, Hsing-Jien Kung, Hsing-Jien Kung   +10 more
doaj   +1 more source

Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics

Frontiers in Toxicology, 2022
Mitochondrial dysfunctions that were not discovered during preclinical and clinical testing have been responsible for at least restriction of use as far as withdrawal of many drugs.
Sylvain Loric, Marc Conti
doaj   +1 more source

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

Nature Communications, 2022
The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors across mitochondrial membranes. The family is highly redundant and their transport activities coupled to metabolic state.
Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, S. Calvo, O. Goldberger, John G Doench, V. Mootha, Hongying Shen   +10 more
semanticscholar   +1 more source

In vitro assessment of stearyl triphenyl phosphonium toxicity in drug-resistant tumor cells

4 open, 2022
Introduction: The triphenyl phosphonium residue is a well-documented mitochondriotropic that has been shown to improve the accumulation of biomolecules in mitochondria. Stearyl triphenyl phosphonium (STPP) modified liposomes have been shown to facilitate
Shah Shrey, Ouellette Miller, D’Souza Gerard G. M.   +2 more
doaj   +1 more source

Mechanisms of venetoclax resistance and solutions

Frontiers in Oncology, 2022
The BCL-2 inhibitor venetoclax is currently approved for treatment of hematologic diseases and is widely used either as monotherapy or in combination strategies.
Jiachen Liu, Yidong Chen, Lihua Yu, Lihua Yang   +3 more
doaj   +1 more source

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages

Frontiers in Immunology, 2023
Introduction Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma.
C. Drummer, Fatma Saaoud, N. Jhala, Ramón Cueto, Yu Sun, Keman Xu, Ying Shao, Yifan Lu, Huimin Shen, Ling Yang, Yan Zhou, Jun Yu, Sheng Wu, N. Snyder, Wenhui Hu, Jiamin Zhuo, Y. Zhong, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +19 more
semanticscholar   +1 more source

Mitochondrial complex II and reactive oxygen species in disease and therapy

Redox Report, 2020
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact ...
Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena   +3 more
doaj   +1 more source