Results 51 to 60 of about 51,036 (282)

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Zhongliu Fangzhi Yanjiu
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping   +3 more
doaj   +1 more source

Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model [PDF]

BackgroundFast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark of cancer. Purely glycolytic ρ0 tumour cells do not form primary tumours unless they acquire healthy mitochondria from their
David Eccles, Michael Berridge, O'Sullivan, David, Alfonso Schmidt, Schmidt, Alfonso, Carole Grasso, Melanie McConnell, Danielle Lewthwaite, Neuzil, Jiri, David O’Sullivan, Georgia Carson, Andrew Wilson, Grasso, Carole, McConnell, Melanie, Carson, Georgia, Patries Herst, Herst, Patries, Wilson, Andrew, Lewthwaite, Danielle, Eccles, David, Jiri Neuzil, Berridge, Michael   +21 more
core   +1 more source

mtDNA copy number: molecular diagnostics and mitochondrial-nuclear crosstalk in frailty and ageing

Patologìâ
Quantitative assessment of mitochondrial DNA copy number is an emerging field of study in the diagnosis and evaluation of age-related pathology and frailty in the elderly, along with the assessment of other acute and chronic diseases that are often ...
C. G. Ward
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!

, 2018
Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate ...
Chinopoulos, Christos, Christos Chinopoulos   +1 more
core   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

Mitochondrial OxPhos: the integrator of the cellular metabolic status [PDF]

, 2021
El sistema de fosforilación oxidativa (OXPHOS) es el único sistema en la célula animal cuyos componentes están codificados en dos genomas, el ADN mitocondrial (mtDNA) y el ADN nuclear (nDNA). El mtDNA es poliploide, de herencia materna y carece de un sistema de recombinación durante su replicación, cuyas consecuencias son una tasa de mutación un orden ...
openaire   +3 more sources

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

, 2021
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non ...
Kimberly A Kew, Darla Liles, Nasreen A Vohra, Myles C Cabot, Miki Kassai, Cameron Schmidt, Kelsey L McLaughlin, Patricia Brophy, Joseph M McClung, James T Hagen, Kelsey H Fisher-Wellman, Margaret AM Nelson, Hannah S Coalson, P Darrell Neufer   +13 more
core   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source