Results 51 to 60 of about 46,956 (278)

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

Scientific Reports, 2023
Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability to discriminate between non-cancerous and cancerous mitochondria.
Ilya N. Boykov, McLane M. Montgomery, James T. Hagen, Raphael T. Aruleba, Kelsey L. McLaughlin, Hannah S. Coalson, Margaret A. Nelson, Andrea S. Pereyra, Jessica M. Ellis, Tonya N. Zeczycki, Nasreen A. Vohra, Su-Fern Tan, Myles C. Cabot, Kelsey H. Fisher-Wellman   +13 more
doaj   +1 more source

Basic mechanism of immune system activation by mitochondria

Immunological Medicine, 2020
Almost 160 years after the discovery of mitochondria, they are known for their production of energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been revealed as a key factor controlling immune cell proliferation and ...
Yukiko Iwasaki, Yusuke Takeshima, Keishi Fujio   +2 more
doaj   +1 more source

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Frontiers in Bioscience-Landmark
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra   +6 more
doaj   +1 more source

Barcode plot of OXPHOS probes.

, 2018
A plot demonstrating the ranks of each of the 1,344 OXPHOS probes with respect to all 420,132 included probes. Each black vertical line represents an OXPHOS probe. A centered cumulative sum is also plotted as a blue line.
Bove, Riley M., Schneider, Julie A., Julie A Schneider, Gyan Srivastava (5565842), Riley M Bove, Schneider, Julie A, Philip L. De Jager (202972), Aubin, Cristin McCabe, David A. Bennett (229710), Bennett, David A, De Jager, Philip Lawrence, De Jager, Philip L, Ellis Patrick, Gyan Srivastava, Chibnik, Lori B, David A Bennett, Ellis Patrick (4219258), Bennett, David A., Chibnik, Lori B., Bove, Riley M, Patrick, Ellis, Cristin McCabe Aubin, Julie A. Schneider (341811), Srivastava, Gyan, Lori B Chibnik, Riley M. Bove (482178), Cristin McCabe Aubin (5565839), Lori B. Chibnik (205940), Philip L De Jager   +28 more
core   +1 more source

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

, 2021
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from non ...
Kimberly A Kew, Darla Liles, Nasreen A Vohra, Myles C Cabot, Miki Kassai, Cameron Schmidt, Kelsey L McLaughlin, Patricia Brophy, Joseph M McClung, James T Hagen, Kelsey H Fisher-Wellman, Margaret AM Nelson, Hannah S Coalson, P Darrell Neufer   +13 more
core   +1 more source

Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model [PDF]

BackgroundFast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark of cancer. Purely glycolytic ρ0 tumour cells do not form primary tumours unless they acquire healthy mitochondria from their
David Eccles, Michael Berridge, O'Sullivan, David, Alfonso Schmidt, Schmidt, Alfonso, Carole Grasso, Melanie McConnell, Danielle Lewthwaite, Neuzil, Jiri, David O’Sullivan, Georgia Carson, Andrew Wilson, Grasso, Carole, McConnell, Melanie, Carson, Georgia, Patries Herst, Herst, Patries, Wilson, Andrew, Lewthwaite, Danielle, Eccles, David, Jiri Neuzil, Berridge, Michael   +21 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Zhongliu Fangzhi Yanjiu
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping   +3 more
doaj   +1 more source

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging [PDF]

, 2016
Defects in mitochondrial biogenesis and function are common in many neurodegenerative disorders, including Huntington’s disease (HD). We have previously shown that in yeast models of HD, enhancement of mitochondrial biogenesis through overexpression of ...
Yi Zhu, Chong Li, Zhu, Yi, Ocampo, Alejandro, Alejandro Ocampo, Andrea L. Ruetenik, Morgan L. McCarthy, R. Grace Zhai, Ruan, Kai, Li, Chong, Kai Ruan, Zhai, R Grace, Ruetenik, Andrea L, Antoni Barrientos, Barrientos, Antoni   +14 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source