Results 51 to 60 of about 56,530 (315)
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch.
Cell Metabolism, 2022 The structural and functional organization of the mitochondrial respiratory chain (MRC) remains intensely debated. Here, we show the co-existence of two separate MRC organizations in human cells and postmitotic tissues, C-MRC and S-MRC, defined by the ...
E. Fernández‐Vizarra +18 more
semanticscholar +1 more source
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Nature Communications, 2021 Arginine plays diverse roles in cellular physiology. As a semi-essential amino acid, arginine deprivation has been used to target cancers with arginine synthesis deficiency.
Chia-Lin Chen +9 more
semanticscholar +1 more source
OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue! [PDF]
, 2018 Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate ...
Chinopoulos, Christos +1 more
core +1 more source
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging [PDF]
BACKGROUND: Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia.
Heskamp, Sandra +15 more
core +4 more sources
Molecular & Cellular Oncology, 2018 We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs).
Lucie de Beauchamp +4 more
doaj +1 more source
Advanced Science, 2023 Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment.
Changqing Wu +17 more
doaj +1 more source
Cadmium treatment induces oxidative phosphorylation (OXPHOS) [PDF]
, 2022 Introduction: Cadmium is a toxic pollutant, and humans are exposed to cadmium by smoking cigarettes. Its effect on mitochondrial OXPHOS is unknown in RAW cells. Methods: RAW cells were exposed to various concentrations of CdCl2 for 24 h.
Parameswaran, Indu
core
AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases
EBioMedicine, 2022 Summary Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large number of studies have elucidated AIF's participation to chromatin condensation during cell
L. Wischhof +3 more
semanticscholar +1 more source
Cells, 2020 Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells.
Mirella Pastore +9 more
doaj +1 more source
Nature Communications, 2022 The folded mitochondria inner membrane-cristae is the structural foundation for oxidative phosphorylation (OXPHOS) and energy production. By mechanically simulating mitochondria morphogenesis, we speculate that efficient sculpting of the cristae is ...
P. Shi +16 more
semanticscholar +1 more source