Results 41 to 50 of about 56,530 (315)

A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC–OXPHOS axis

Journal of Translational Medicine, 2023
Background Ovarian cancer (OC) is the most lethal malignant gynecological tumor type for which limited therapeutic targets and drugs are available. Enhanced mitochondrial oxidative phosphorylation (OXPHOS), which enables cell growth, migration, and ...
Rui-bin Jiang, Zhongjian Chen, Maowei Ni, Xia Li, H. Ying, J. Fen, Danying Wan, Chanjuan Peng, Wei Zhou, Linhui Gu   +9 more
semanticscholar   +1 more source

Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

Blood Advances, 2023
Key Points • GLUT1 is essential for energy metabolism of murine MLL::AF9 LSCs in the bone marrow microenvironment.• GLUT1 and OXPHOS inhibition eliminates human AML cells.
Maria Rodriguez-Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Somadri Ghosh, Leal Oburoglu, Antoni Falqués-Costa, Kishan Bellamkonda, M. Ehinger, Pablo Peña-Martínez, Noelia Puente-Moncada, H. Lilljebjörn, J. Cammenga, C. Pronk, V. Lazarevic, T. Fioretos, Anna K. Hagström-Andersson, N. Woods, Marcus Järås   +17 more
semanticscholar   +1 more source

ILF2 cooperates with E2F1 to maintain mitochondrial homeostasis and promote small cell lung cancer progression

Cancer Biology & Medicine, 2019
Objective Mitochondria play multifunctional roles in carcinogenesis. Deciphering uncertainties of molecular interactions within mitochondria will promote further understanding of cancer.
Meng Zhao, Yahui Liu, Jiao Chang, Jin Qi, Ran Liu, Yongwang Hou, Yanhui Wang, Xinwei Zhang, Lu Qiao, Li Ren   +9 more
doaj   +1 more source

Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer

bioRxiv, 2022
Background Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal.
S. Sriramkumar, Riddhi Sood, Thomas D. Huntington, A. Ghobashi, Weini Wang, K. Nephew, Heather M. O’Hagan   +6 more
semanticscholar   +1 more source

Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

Cells, 2020
Cytochrome c oxidase (COX) is regulated through tissue-, development- or environment-controlled expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms ...
David Pajuelo Reguera, Kristýna Čunátová, Marek Vrbacký, Alena Pecinová, Josef Houštěk, Tomáš Mráček, Petr Pecina   +6 more
doaj   +1 more source

The transmission of OXPHOS disease and methods to prevent this [PDF]

Human Reproduction Update, 2005
Abstract Diseases owing to defects of oxidative phosphorylation (OXPHOS) affect approximately 1 in 8000 individuals. Clinical manifestations can be extremely variable and range from single-affected tissues to multisystemic syndromes. In general, tissues with a high energy demand, like brain, heart and muscle, are affected.
Jacobs, LJAM, de Wert, GMWR (Guido), Geraedts, JPM, Coo, IFM, Smeets, HJM   +4 more
openaire   +3 more sources

Barcode plot of OXPHOS probes. [PDF]

, 2018
A plot demonstrating the ranks of each of the 1,344 OXPHOS probes with respect to all 420,132 included probes. Each black vertical line represents an OXPHOS probe. A centered cumulative sum is also plotted as a blue line.
Bove, Riley M., Schneider, Julie A., Julie A Schneider, Gyan Srivastava (5565842), Riley M Bove, Schneider, Julie A, Philip L. De Jager (202972), Aubin, Cristin McCabe, David A. Bennett (229710), Bennett, David A, De Jager, Philip Lawrence, De Jager, Philip L, Ellis Patrick, Gyan Srivastava, Chibnik, Lori B, David A Bennett, Ellis Patrick (4219258), Bennett, David A., Chibnik, Lori B., Bove, Riley M, Patrick, Ellis, Cristin McCabe Aubin, Julie A. Schneider (341811), Srivastava, Gyan, Lori B Chibnik, Riley M. Bove (482178), Cristin McCabe Aubin (5565839), Lori B. Chibnik (205940), Philip L De Jager   +28 more
core   +2 more sources

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions

Molecular & Cellular Oncology, 2021
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative ...
Eduardo Silva-Pavez, Ulises Ahumada-Castro, Alenka Lovy, Julio Cesar Cárdenas   +3 more
doaj   +1 more source

The regulation of OXPHOS by extramitochondrial calcium

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Despite extensive research, the regulation of mitochondrial function is still not understood completely. Ample evidence shows that cytosolic Ca2+ has a strategic task in co-ordinating the cellular work load and the regeneration of ATP by mitochondria. Currently, the paradigmatic view is that Cacyt2+ taken up by the Ca2+ uniporter activates the matrix ...
Gellerich, Frank N., Gizatullina, Zemfira, Trumbeckaite, Sonata, Nguyen, Huu P., Pallas, Thilo, Arandarcikaite, Odeta, Vielhaber, Stephan, Seppet, Enn, Striggow, Frank   +8 more
openaire   +2 more sources

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

Clinical and Translational Medicine, 2022
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly expressed in various cancer entities, suggesting tumour‐promoting functions.
Anna Reustle, Lena‐Sophie Menig, Patrick Leuthold, Ute Hofmann, Viktoria Stühler, Christian Schmees, Michael Becker, Mathias Haag, Verena Klumpp, Stefan Winter, Florian A. Büttner, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Jens Bedke, Matthias Schwab, Elke Schaeffeler   +18 more
doaj   +1 more source