Results 41 to 50 of about 51,036 (282)

The transmission of OXPHOS disease and methods to prevent this [PDF]

Human Reproduction Update, 2005
Abstract Diseases owing to defects of oxidative phosphorylation (OXPHOS) affect approximately 1 in 8000 individuals. Clinical manifestations can be extremely variable and range from single-affected tissues to multisystemic syndromes. In general, tissues with a high energy demand, like brain, heart and muscle, are affected.
Jacobs, LJAM, de Wert, GMWR (Guido), Geraedts, JPM, Coo, IFM, Smeets, HJM   +4 more
openaire   +3 more sources

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

Clinical and Translational Medicine, 2022
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly expressed in various cancer entities, suggesting tumour‐promoting functions.
Anna Reustle, Lena‐Sophie Menig, Patrick Leuthold, Ute Hofmann, Viktoria Stühler, Christian Schmees, Michael Becker, Mathias Haag, Verena Klumpp, Stefan Winter, Florian A. Büttner, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Jens Bedke, Matthias Schwab, Elke Schaeffeler   +18 more
doaj   +1 more source

Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

Molecular & Cellular Oncology, 2018
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs).
Lucie de Beauchamp, Pablo Baquero, Elodie M. Kuntz, Eyal Gottlieb, G. Vignir Helgason   +4 more
doaj   +1 more source

NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition

Advanced Science, 2023
Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment.
Changqing Wu, Yu'e Liu, Wenju Liu, Tianhui Zou, Shaojuan Lu, Chengjie Zhu, Le He, Jie Chen, Lan Fang, Lin Zou, Ping Wang, Lihong Fan, Hongxiang Wang, Han You, Juxiang Chen, Jing‐Yuan Fang, Cizhong Jiang, Yufeng Shi   +17 more
doaj   +1 more source

Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives

Cells, 2020
Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells.
Mirella Pastore, Giulia Lori, Alessandra Gentilini, Maria Letizia Taddei, Giovanni Di Maira, Claudia Campani, Stefania Recalcati, Pietro Invernizzi, Fabio Marra, Chiara Raggi   +9 more
doaj   +1 more source

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types

Scientific Reports, 2023
Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability to discriminate between non-cancerous and cancerous mitochondria.
Ilya N. Boykov, McLane M. Montgomery, James T. Hagen, Raphael T. Aruleba, Kelsey L. McLaughlin, Hannah S. Coalson, Margaret A. Nelson, Andrea S. Pereyra, Jessica M. Ellis, Tonya N. Zeczycki, Nasreen A. Vohra, Su-Fern Tan, Myles C. Cabot, Kelsey H. Fisher-Wellman   +13 more
doaj   +1 more source

Basic mechanism of immune system activation by mitochondria

Immunological Medicine, 2020
Almost 160 years after the discovery of mitochondria, they are known for their production of energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been revealed as a key factor controlling immune cell proliferation and ...
Yukiko Iwasaki, Yusuke Takeshima, Keishi Fujio   +2 more
doaj   +1 more source

Oxphos Promotes Apoptotic Resistance and Cellular Persistence in TH17 Cells in the Periphery and Tumor Microenvironment [PDF]

, 2022
T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune ...
Goldstein, Daniel R, Kryczek, Ilona, Lyssiotis, Costas A, Loesel, Kristen, Hayashi, Atsushi, Opipari, Anthony W, Magnuson, Brian, Zou, Weiping, Lin, Lin, Sajjakulnukit, Peter, Lin, Jason, Correa, Luis O, Mbah, Nneka E, Andren, Anthony, Argüello, Rafael J, Hong, Hanna S, Chen, Judy, Zhang, Li, Shan, Mengrou, Xie, Yuying, Kamada, Nobuhiko, Franchi, Luigi, Carty, Shannon A, Lei, Yu Leo, Li, Zhaoheng   +24 more
core   +1 more source

OXPHOS inhibitors, metabolism and targeted therapies in cancer

Biochemical Pharmacology, 2023
More and more studies highlight the complex metabolic characteristics and plasticity of cancer cells. To address these specificities and explore the associated vulnerabilities, new metabolism-targeting therapeutic strategies are being developed. It is more and more accepted that cancer cells do not produce their energy only from aerobic glycolysis, as ...
Cadassou, Octavia, Jordheim, Lars Petter
openaire   +3 more sources

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Frontiers in Bioscience-Landmark
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra   +6 more
doaj   +1 more source