Results 41 to 50 of about 46,956 (278)

Mitochondrial complex II and reactive oxygen species in disease and therapy

Redox Report, 2020
Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact ...
Katerina Hadrava Vanova, Michal Kraus, Jiri Neuzil, Jakub Rohlena   +3 more
doaj   +1 more source

ILF2 cooperates with E2F1 to maintain mitochondrial homeostasis and promote small cell lung cancer progression

Cancer Biology & Medicine, 2019
Objective Mitochondria play multifunctional roles in carcinogenesis. Deciphering uncertainties of molecular interactions within mitochondria will promote further understanding of cancer.
Meng Zhao, Yahui Liu, Jiao Chang, Jin Qi, Ran Liu, Yongwang Hou, Yanhui Wang, Xinwei Zhang, Lu Qiao, Li Ren   +9 more
doaj   +1 more source

Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

Cells, 2020
Cytochrome c oxidase (COX) is regulated through tissue-, development- or environment-controlled expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms ...
David Pajuelo Reguera, Kristýna Čunátová, Marek Vrbacký, Alena Pecinová, Josef Houštěk, Tomáš Mráček, Petr Pecina   +6 more
doaj   +1 more source

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions

Molecular & Cellular Oncology, 2021
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative ...
Eduardo Silva-Pavez, Ulises Ahumada-Castro, Alenka Lovy, Julio Cesar Cárdenas   +3 more
doaj   +1 more source

The transmission of OXPHOS disease and methods to prevent this [PDF]

Human Reproduction Update, 2005
Abstract Diseases owing to defects of oxidative phosphorylation (OXPHOS) affect approximately 1 in 8000 individuals. Clinical manifestations can be extremely variable and range from single-affected tissues to multisystemic syndromes. In general, tissues with a high energy demand, like brain, heart and muscle, are affected.
Jacobs, LJAM, de Wert, GMWR (Guido), Geraedts, JPM, Coo, IFM, Smeets, HJM   +4 more
openaire   +3 more sources

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

Clinical and Translational Medicine, 2022
Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly expressed in various cancer entities, suggesting tumour‐promoting functions.
Anna Reustle, Lena‐Sophie Menig, Patrick Leuthold, Ute Hofmann, Viktoria Stühler, Christian Schmees, Michael Becker, Mathias Haag, Verena Klumpp, Stefan Winter, Florian A. Büttner, Steffen Rausch, Jörg Hennenlotter, Falko Fend, Marcus Scharpf, Arnulf Stenzl, Jens Bedke, Matthias Schwab, Elke Schaeffeler   +18 more
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The regulation of OXPHOS by extramitochondrial calcium

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Despite extensive research, the regulation of mitochondrial function is still not understood completely. Ample evidence shows that cytosolic Ca2+ has a strategic task in co-ordinating the cellular work load and the regeneration of ATP by mitochondria. Currently, the paradigmatic view is that Cacyt2+ taken up by the Ca2+ uniporter activates the matrix ...
Gellerich, Frank N., Gizatullina, Zemfira, Trumbeckaite, Sonata, Nguyen, Huu P., Pallas, Thilo, Arandarcikaite, Odeta, Vielhaber, Stephan, Seppet, Enn, Striggow, Frank   +8 more
openaire   +2 more sources

NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition

Advanced Science, 2023
Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment.
Changqing Wu, Yu'e Liu, Wenju Liu, Tianhui Zou, Shaojuan Lu, Chengjie Zhu, Le He, Jie Chen, Lan Fang, Lin Zou, Ping Wang, Lihong Fan, Hongxiang Wang, Han You, Juxiang Chen, Jing‐Yuan Fang, Cizhong Jiang, Yufeng Shi   +17 more
doaj   +1 more source

Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

Molecular & Cellular Oncology, 2018
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs).
Lucie de Beauchamp, Pablo Baquero, Elodie M. Kuntz, Eyal Gottlieb, G. Vignir Helgason   +4 more
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Multifaceted Aspects of Metabolic Plasticity in Human Cholangiocarcinoma: An Overview of Current Perspectives

Cells, 2020
Cholangiocarcinoma (CCA) is a deadly tumor without an effective therapy. Unique metabolic and bioenergetics features are important hallmarks of tumor cells.
Mirella Pastore, Giulia Lori, Alessandra Gentilini, Maria Letizia Taddei, Giovanni Di Maira, Claudia Campani, Stefania Recalcati, Pietro Invernizzi, Fabio Marra, Chiara Raggi   +9 more
doaj   +1 more source