Results 61 to 70 of about 56,530 (315)

Loss of LUC7L2 and U1 snRNP Subunits Shifts Energy Metabolism from Glycolysis to OXPHOS

Molecules and Cells, 2021
SUMMARY Oxidative phosphorylation (OXPHOS) and glycolysis are the two major pathways for ATP production. The reliance on each varies across tissues and cell states, and can influence susceptibility to disease.
Alexis A. Jourdain, Bridget E. Begg, E. Mick, Hardik Shah, S. Calvo, Owen S. Skinner, Rohit Sharma, S. Blue, Gene W. Yeo, C. Burge, V. Mootha   +10 more
semanticscholar   +1 more source

Basic mechanism of immune system activation by mitochondria

Immunological Medicine, 2020
Almost 160 years after the discovery of mitochondria, they are known for their production of energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been revealed as a key factor controlling immune cell proliferation and ...
Yukiko Iwasaki, Yusuke Takeshima, Keishi Fujio   +2 more
doaj   +1 more source

Metabolic Plasticity and Cancer Stem Cell Metabolism: Exploring the Glycolysis-OXPHOS Switch as a Mechanism for Resistance and Tumorigenesis

Stem Cell Reviews and Reports
Metabolic plasticity is a hallmark of cancer, enabling tumour cells to grow and adapt to microenvironmental stress, eventually contributing to tumour heterogeneity.
Li Qing Keoh, Ching-Feng Chiu, T. S. Ramasamy   +2 more
semanticscholar   +1 more source

OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential

EMBO Reports, 2021
Reduction of mitochondrial membrane potential (Δψm) is a hallmark of mitochondrial dysfunction. It activates adaptive responses in organisms from yeast to human to rewire metabolism, remove depolarized mitochondria, and degrade unimported precursor ...
Siqi Liu, Shanshan Liu, Baiyu He, Lanlan Li, Lin Li, Jiawen Wang, T. Cai, She Chen, Hui Jiang   +8 more
semanticscholar   +1 more source

Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses

bioRxiv, 2021
Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the “classically activated” M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as ...
M. Lundahl, Morgane Mitermite, D. Ryan, Sarah Case, Niamh C. Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, F. Lebre, Aoife L Gorman, Bojan Stojkovic, A. Bracken, C. Frezza, Frederick J. Sheedy, Eoin M. Scanlan, L. O’Neill, S. Gordon, E. Lavelle   +17 more
semanticscholar   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium

Frontiers in Bioscience-Landmark
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra   +6 more
doaj   +1 more source

An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis

Nature Metabolism
Coenzyme Q (Q) is a key lipid electron transporter, but several aspects of its biosynthesis and redox homeostasis remain undefined. Various flavoproteins reduce ubiquinone (oxidized form of Q) to ubiquinol (QH2); however, in eukaryotes, only oxidative ...
Juan Cruz Herrero Martín, Beñat Salegi Ansa, G. Álvarez-Rivera, Sonia Domínguez-Zorita, P. Rodríguez-Pombo, B. Pérez, Enrique Calvo, A. Paradela, David G. Míguez, Alejandro Cifuentes, J. Cuezva, L. Formentini   +11 more
semanticscholar   +1 more source

Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition

Blood Advances, 2021
Key Points OxPhos inhibition induces mitochondrial trafficking from BM stroma cells to AML cells accompanied by mitochondrial fission and mitophagy.
Kaori Saito, Qi Zhang, Haeun Yang, Kotoko Yamatani, Tomohiko Ai, V. Ruvolo, Natalia Baran, Tianyu Cai, Helen Ma, R. Jacamo, Vinitha M Kuruvilla, Junichi Imoto, S. Kinjo, K. Ikeo, Kaori Moriya, Koya Suzuki, T. Miida, Yong-Mi Kim, C. Vellano, M. Andreeff, J. Marszalek, Y. Tabe, M. Konopleva   +22 more
semanticscholar   +1 more source